Month: February 2023

Copper-Catalyzed, N-Directed Distal C(sp³)-H Functionalization toward Azepanes was written by Yang, Jia-Wen;Tan, Guang-Qiang;Liang, Kai-Cheng;Xu, Ke-Dong;Su, Ma;Liu, Feng. And the article was included in Organic Letters in 2022.Related Products of 34946-82-2 This article mentions the following:

A copper-catalyzed formal [5 + 2] aza-annulation of N-fluorosulfonamides and 1,3-dienes/1,3-enynes for synthesis of structurally diverse alkene/alkyne-containing azepanes such as I [R¹ = H, Me, Et; R² = Me, Et; R¹R² = (CH²)₄, (CH²)₅; R³ = H, Me; R⁴ = Ph, n-hexyl, 4-MeC₆H₄, etc.; Ar = Ph, 4-MeOC₆H₄, 2-thienyl, etc.] and II [Ar¹ = Ph, 4-ClC₆H₄, 4-MeC₆H₄, etc.; Ar = Ph, 4-phenylphenyl, 4-MeC₆H₄, 4-BrC₆H₄, 4-MeOC₆H₄] was reported. The reaction features selective functionalization of distal unactivated C(sp³)-H bonds and a broad substrate scope, thus allowing the late-stage modification of pharmaceuticals and natural products. A radical mechanism involving 1,5-hydrogen atom transfer of N-radicals, facile coupling of alkyl radicals with 1,3-dienes/1,3-enynes, and the construction of azepane motifs via C-N bond formation was proposed. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Related Products of 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Copper catalyst has received great attention owing to the low toxicity and low cost. These ligands enable the reaction promoted in mild condition. The reaction scope has also been greatly expanded, rendering this copper-based cross-coupling attractive for both academia and industry. Related Products of 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Total synthesis of himastatin was written by D’Angelo, Kyan A.;Schissel, Carly K.;Pentelute, Bradley L.;Movassaghi, Mohammad. And the article was included in Science (Washington, DC, United States) in 2022.Application of 34946-82-2 This article mentions the following:

The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound’s biogenesis. Combining this approach with a modular synthesis enabled expedient access to more than a dozen designed derivatives of himastatin, including synthetic probes that provide insight into its antibiotic activity. The synthesis and study of antibiotic natural products with unique structures and mechanisms of action represents a proven strategy to combat the public health crisis posed by antibiotic-resistant bacteria. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Application of 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The evolution of transition metal catalysts has attained a stage of civilization that authorizes for an extensive scope of chemical bonds formation partners to be combined efficiently. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.Application of 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Organomagnesiate-Promoted Enantioselective Cascade Process: Straightforward Access to Chiral 3-Substituted Isobenzofuranones was written by Touchet, Sabrina;Kommidi, Sai Shradha Reddy;Gros, Philippe C.. And the article was included in ChemistrySelect in 2018.Computed Properties of C24H34O2 This article mentions the following:

The bimetallic organomagnesiate complex (S)-(BIPHEN)BuMgLi was reported as a dual efficient halogen-metal exchange and chirality transfer agent in the reaction of ethyl-2-iodobenzoate with aldehydes leading to the formation of various chiral 3-substituted isobenzofuranones in good yields and enantiomeric ratios. In the experiment, the researchers used many compounds, for example, (S)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol (cas: 205927-03-3Computed Properties of C24H34O2).

(S)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol (cas: 205927-03-3) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to the earth-abundant, low toxicity and inexpensive. Due to these characteristics, copper nanoparticles have generated a great deal of interest especially in the field of catalysis. Computed Properties of C24H34O2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Rhodium-catalyzed enone carbonyl directed C-H activation for the synthesis of indanones containing all-carbon quaternary centers was written by Lou, Jiang;Han, Wenjia;Liu, Zhuqing;Xiao, Jiaqi. And the article was included in Organic Chemistry Frontiers in 2021.Quality Control of copper(ii)hexafluor-2,4-pentanedionate This article mentions the following:

Rh(III)-Catalyzed enone carbonyl directed annulative coupling of α-aroyl ketene dithioacetals and diazo compounds were realized via aryl and olefinic C-H bond activation. This transformation offered highly functionalized indanone derivatives bearing a quaternary carbon stereocenter at the β-position. The protocol exhibited high efficiency, broad substrate scope, and high compatibility with functional groups. In the experiment, the researchers used many compounds, for example, copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4Quality Control of copper(ii)hexafluor-2,4-pentanedionate).

copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4) belongs to copper catalysts. Transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents belong to the most important cross-coupling reaction in organic synthesis. Copper of different valence states can be used to catalyze the coupling reaction, especially the Ullmann coupling reaction. Quality Control of copper(ii)hexafluor-2,4-pentanedionate

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Cu-Catalyzed Intermolecular γ-Site C-H Amination of Cyclohexenone Derivatives: The Benefit of Bifunctional Ligands was written by Zhao, Xin;Yang, Fang;Zou, Shao-Yu;Zhou, Qian-Qian;Chen, Zi-Sheng;Ji, Kegong. And the article was included in ACS Catalysis in 2022.Recommanded Product: 34946-82-2 This article mentions the following:

Utilizing 1,10-phenanthroline-type bifunctional ligands, an efficient Cu-catalyzed intermol. site-selective remote C-H amination using cyclohexenone derivatives and anilines was realized. The amide group installed on the bifunctional ligand played a key role in stabilizing the N-centered radical generated in-situ to realize C-N-directed formation. Meanwhile, a useful catalytic system for site-selective intermol. remote γ-C-H amination to p-aminophenols and γ-aminated enones was established. This economical and practical approach using oxygen as the terminal oxidant was mild and environmentally friendly. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Recommanded Product: 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to the earth-abundant, inexpensive and low toxicity. These ligands enable the reaction promoted in mild condition. The reaction scope has also been greatly expanded, rendering this copper-based cross-coupling attractive for both academia and industry. Recommanded Product: 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Coordination Chemistry of 2,2′-Bipyridyl- and 2,2′:6′,2”-Terpyridyl-Substituted BEDT-TTFs: Formation of a Supramolecular Capsule Motif by the Iron(II) Tris Complex of 2,2′-Bipyridine-4-thiomethyl-BEDT-TTF was written by Wang, Qiang;Martin, Lee;Blake, Alexander J.;Day, Peter;Akutsu, Hiroki;Wallis, John D.. And the article was included in Inorganic Chemistry in 2016.Recommanded Product: 14781-45-4 This article mentions the following:

Mols. of tris(2,2′-bipyridine-4-thiomethyl-BEDT-TTF)iron(II) (BEDT-TTF = bis(ethylenedithio)tetrathiafulvalene) assemble in pairs to form a novel supramol. capsular structure in the solid state. Three BEDT-TTF residues from one complex lie in the three grooves between coordinated bipyridines of the other complex, and vice versa, to form a capsule with 3-fold rotational symmetry and an internal volume of ∼160 ų. Further aspects of the coordination chem. of this ligand, its 6-substituted isomer, and the 2,2′:6’2”-terpyridyl-4′-thiomethyl-BEDT-TTF analog are described, [M(Lⁿ)₃](PF₆)₂ and [M(L²)(hfac)₂] , where M = Zn, Mn, Fe, Co, Ni, or Cu, Lⁿ = bipyridines terpyridine substituted tetrathiafulvalenes, and hfac = hexafluoroacetylacetonato. In the experiment, the researchers used many compounds, for example, copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4Recommanded Product: 14781-45-4).

copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4) belongs to copper catalysts. Copper catalyst has received great attention owing to the low toxicity and low cost. These ligands enable the reaction promoted in mild condition. The reaction scope has also been greatly expanded, rendering this copper-based cross-coupling attractive for both academia and industry. Recommanded Product: 14781-45-4

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Construction of substituted pyrazolo[4,3-c]quinolines via [5+1] cyclization of pyrazole-arylamines with alcohols/amines in one pot was written by Tang, Dong;Mu, Yangxiu;Iqbal, Zafar;He, Lili;Jiang, Rui;Hou, Jing;Yang, Zhixiang;Yang, Minghua. And the article was included in Journal of Heterocyclic Chemistry in 2022.Quality Control of Copper(II) trifluoromethanesulfonate This article mentions the following:

An efficient protocol had been developed for the synthesis of pyrazolo[4,3-c]quinoline derivatives I [R¹ = Me, Ph, 3-pyridyl, etc.; R² = Ph, 4-MeC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 4-NCC₆H₄; R³ = Ph, 1-naphthyl, 2-thienyl, etc.], by reacting (1H-pyrazol-5-yl)anilines and readily available alcs./amines. A wide range of substrates with diverse functional groups were smoothly converted to the corresponding products in moderate to good yields, under optimal reaction conditions. Furthermore, the strategy also proceeded well with thiol and amino acid to access pyrazolo[4,3-c]quinoline derivatives In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Quality Control of Copper(II) trifluoromethanesulfonate).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to low toxicity and inexpensive, earth-abundant. Due to these characteristics, copper nanoparticles have generated a great deal of interest especially in the field of catalysis. Quality Control of Copper(II) trifluoromethanesulfonate

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Copper/Iodine-Catalyzed Hydroxyamination of Alkenyl Keto Oximes Using DMSO as the Oxygen Atom Source and Medium was written by Yin, Xiao-Qiu;Deng, Wei;Xiang, Jian-Nan. And the article was included in European Journal of Organic Chemistry in 2022.Quality Control of Copper(II) trifluoromethanesulfonate This article mentions the following:

A new copper/I2-catalyzed hydroxyamination of alkenes of unsaturated keto oximes with DMSO as the hydroxy oxygen atom source and medium for assembling 2-(2-hydroxyalkyl)-3,4-dihydro-2H-pyrrole 1-oxides is described. Mechanistic studies suggest that the reaction is terminated by a single electron oxidation and subsequent nucleophilic reaction. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Quality Control of Copper(II) trifluoromethanesulfonate).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents belong to the most important cross-coupling reaction in organic synthesis. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.Quality Control of Copper(II) trifluoromethanesulfonate

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Synthesis of carbazoles based on gold-copper tandem catalysis was written by Choi, Subin;Srinivasulu, Vunnam;Ha, Sujin;Park, Cheol-Min. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Formula: C10H2CuF12O4 This article mentions the following:

In the presence of Au(Ph₃P)Cl, AgOTf, and Cu(hfacac)₂, and using MnO₂ as a stoichiometric oxidant, aminophenylalkynyl diazodicarbonyl compounds (diazo anilinoalkynes) such as I underwent chemoselective tandem hydroamination, insertion, and aromatization reactions to yield hydroxycarbazoles such as II in 49-82% yields. The aminophenylalkynyl diazodicarbonyl compounds were prepared in four steps (three-step longest linear sequences) from anilines, propargyl bromides, and dicarbonyl compounds In the experiment, the researchers used many compounds, for example, copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4Formula: C10H2CuF12O4).

copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to low toxicity and inexpensive, earth-abundant. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.Formula: C10H2CuF12O4

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Copper(II)-catalyzed selective CAr-H bond formylation: synthesis of dialdehyde aniline was written by Guo, Shiwei;Li, Yinghua;Fan, Weibin;Liu, Zhiqi;Huang, Deguang. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2022.Category: copper-catalyst This article mentions the following:

A simple and efficient method for the synthesis of dialdehyde aniline I [R = 2-Me, 3-F, 2-Ph, etc.] in good yields (up to 83%) was explored using Cu(OTf)₂ as the catalyst, Selectfluor as the radical initiator, and DMSO as both the carbon and oxygen sources. Exptl. studies indicated that the reaction was achieved by the formylation of two CAr-H bonds, first at the para-position and then at the ortho-position. A possible mechanism was proposed, including the thermal homolysis of Selectfluor, the Cu(II)-facilitated formylation of the CAr-H bonds, and the hydrolysis of the amide under alk. conditions in air atm. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Category: copper-catalyst).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The evolution of transition metal catalysts has attained a stage of civilization that authorizes for an extensive scope of chemical bonds formation partners to be combined efficiently. The copper-mediated C-C, C-O, C-N, and C-S bond formation is a part of one oldest reaction, emphasizing the Ullmann cross-coupling reaction.Category: copper-catalyst

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”