Month: February 2023

Copper-catalyzed asymmetric 1,6-conjugate addition of in situ generated para-quinone methides with β-ketoesters was written by Wang, Yi-Feng;Wang, Chao-Jie;Feng, Qing-Zhou;Zhai, Jing-Jing;Qi, Suo-Suo;Zhong, Ai-Guo;Chu, Ming-Ming;Xu, Dan-Qian. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Recommanded Product: 34946-82-2 This article mentions the following:

A Cu-catalyzed asym. 1,6-conjugate addition of in situ generated para-quinone methides (p-QMs) with β-ketoester has been developed to construct a ketoester skeleton bearing an adjacent tertiary-quaternary carbon stereocenter in good yields and high enantioselectivities. This is the first example of metal-catalyzed asym. transformations of the in situ generated p-QMs, avoiding using pre-synthesized p-QMs requiring bulky 2,6-substitutions and highlighting a new dual catalytic activation with the chiral bis(oxazoline)-metal complex acting as a normal Lewis acid to activate the β-ketoesters and a source of Bronsted acid responsible for generating the p-QMs in situ. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Recommanded Product: 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to low toxicity and inexpensive, earth-abundant. The copper-mediated C-C, C-O, C-N, and C-S bond formation is a part of one oldest reaction, emphasizing the Ullmann cross-coupling reaction.Recommanded Product: 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Synthesis of the Icetexane Diterpenoids (±)-Rosmaridiphenol, (±)-Pisiferin, and (±)-Barbatusol from Abietane was written by Le, Thuy Quynh;Lee, JuHui;Oh, Chang Ho. And the article was included in Synlett in 2022.Related Products of 34946-82-2 This article mentions the following:

We report the rearrangement of abietane core with trifluoromethanesulfonic anhydride in pyridine to afford the icetexane core, a key intermediate for total syntheses of the structurally intriguing and biol. active compounds (±)-barbatusol (I), (±)-rosmaridiphenol (II), and (±)-pisiferin (III). In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Related Products of 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents has turned up as an exceedingly robust synthetic tool. Copper nanoparticles can also catalyze the coupling reaction of nitrogen-containing nucleophiles, phenols, thiols, xanthogenates, selenium ruthenium nucleophiles and the like.Related Products of 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Structural and Magnetic Properties of 2p-3d-4f Hetero-Tri-Spin Chains Comprising [{Cu(hfac)₂-Radical}₂] Dimers and Ln(hfac)₃ (hfac = hexafluoroacetylacetonate) was written by Zhu, Mei;Yang, Meng;Wang, Juanjuan;Li, Hongdao;Li, Licun. And the article was included in Chemistry – An Asian Journal in 2016.SDS of cas: 14781-45-4 This article mentions the following:

A new family of 2p-3d-4f hetero-tri-spin complexes [Ln(hfac)₃{Cu(hfac)₂(NIT-3 PyPh)}₂] (Ln = Gd (1), Tb (2), Dy (3), Ho (4); NIT-3 PyPh = 2-[4-(3-pyridinylmethoxy)phenyl]-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide; hfac = hexafluoroacetylacetonate) were synthesized. The four complexes possess a 1-dimensional chain structure in which two radical ligands join two Cu(hfac)₂ mols. to form a [{Cu(hfac)₂-rad}₂] dimer cycle and the dimer rings are linked by Ln(hfac)₃ units. Magnetic studies show that ferromagnetic exchange couplings exist between the coordinated NO groups of radical ligands and metal ions. Field-induced slow relaxation of the magnetization was observed in the Tb and Dy compounds In the experiment, the researchers used many compounds, for example, copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4SDS of cas: 14781-45-4).

copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4) belongs to copper catalysts. Transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents belong to the most important cross-coupling reaction in organic synthesis. Copper nanoparticles can catalyze the Ullmann coupling reaction in a wide range of applications.SDS of cas: 14781-45-4

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Pt-alloy decorated graphene as an efficient electrocatalyst for PEM fuel cell reactions was written by Das, Elif;Alkan Gursel, Selmiye;Bayrakceken Yurtcan, Ayse. And the article was included in Journal of Supercritical Fluids in 2020.Application In Synthesis of copper(ii)hexafluor-2,4-pentanedionate This article mentions the following:

Herein, for the first time, bimetallic nanoparticles supported on graphene nanoplatelets (PtNi/GNPs, PtFe/GNPs, PtCu/GNPs) were prepared as sequentially through supercritical carbon dioxide (scCO₂) technique. The physicochem. properties of the prepared catalysts were characterized by XRD, TEM, EDX, TGA, ICP-MS and Raman spectroscopy. Furthermore, the catalytic activity of bimetallic catalysts was tested using a three-cell cyclic voltammetry. PtNi/GNPs catalyst showed the best catalytic activity towards both hydrogen oxidation reaction (HOR) and oxygen reduction reaction (ORR). Finally, to investigate the improvement of the cell performances, polarization curves were presented. It was found that the PtNi/GNPs catalyst exhibited highest performance (907.5 mA/cm ², 0.54 mW/cm ² @ 0.6 V) when the catalyst was used as anode electrode. We believe that this work will serve as a guide to the fuel cell research community in the selection of a promising route for the development of new low-cost and efficient electrocatalysts for PEMFC. In the experiment, the researchers used many compounds, for example, copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4Application In Synthesis of copper(ii)hexafluor-2,4-pentanedionate).

copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4) belongs to copper catalysts. The evolution of transition metal catalysts has attained a stage of civilization that authorizes for an extensive scope of chemical bonds formation partners to be combined efficiently. Copper of different valence states can be used to catalyze the coupling reaction, especially the Ullmann coupling reaction. Application In Synthesis of copper(ii)hexafluor-2,4-pentanedionate

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Kilogram-Scale Synthesis of 2′-C-Methyl-arabino-Uridine from Uridine via Dynamic Selective Dipivaloylation was written by Chung, John Y. L.;Kassim, Amude M.;Simmons, Bryon;Davis, Tyler A.;Song, Zhiguo J.;Limanto, John;Dalby, Stephen M.;He, Cyndi Q.;Calabria, Ralph;Wright, Timothy J.;Campeau, Louis-Charles. And the article was included in Organic Process Research & Development in 2022.Application In Synthesis of Copper(II) trifluoromethanesulfonate This article mentions the following:

We report a practical 3′,5′-diprotection strategy suitable for the kilogram-scale preparation of 2′-C-methyl-arabino-uridine, a key intermediate in the synthesis of the HCV NS5B inhibitor uprifosbuvir. Starting from uridine, dipivaloylation afforded an ~2:1 mixture of 3′,5′- and 2′,5′-dipivaloyluridine. Subjecting this mixture to TEMPO/bleach oxidation promoted a dynamic acylation migration-selective oxidation to afford the 2′-ketone in 65% yield. Alternatively, treatment with 1 equiv of BF₃ etherate led to the crystallization-driven equilibration and precipitation of 3′,5′-dipivaloyluridine·BF₃ complex in a >50:1 ratio. After salt break, this mixture was oxidized in the presence of TEMPO/AcOOH to afford the 2′-ketone in 90% yield. Subsequent α-facial-selective methylation with MeMgBr/MnCl₂ afforded 3′,5′-dipivaloylated 2′-C-methyl-arabino-uridine. This three-step process was successfully demonstrated on a multi-kilogram scale to afford the key intermediate for the manufacture of uprifosbuvir. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Application In Synthesis of Copper(II) trifluoromethanesulfonate).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents belong to the most important cross-coupling reaction in organic synthesis. Due to these characteristics, copper nanoparticles have generated a great deal of interest especially in the field of catalysis. Application In Synthesis of Copper(II) trifluoromethanesulfonate

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

New Enantiomerically Pure Alkylimido Molybdenum-Based Alkylidene Complexes. Synthesis, Characterization, and Activity as Chiral Olefin Metathesis Catalysts was written by Pilyugina, Tatiana S.;Schrock, Richard R.;Mueller, Peter;Hoveyda, Amir H.. And the article was included in Organometallics in 2007.Related Products of 205927-03-3 This article mentions the following:

Molybdenum olefin metathesis catalysts that contain aliphatic 1-phenylcyclohexylimido (NPhCy) and 2-phenyl-2-adamantylimido (NPhAd) groups and (S)-Biphen or (R)-Trip ligands (Biphen = 3,3′-di-tert-butyl-5,5′,6,6′-tetramethyl-1,1′-biphenyl-2,2′-diolate; Trip = 3,3′-bis(2,4,6-triisopropylphenyl)-2,2′-binaphtholate) have been prepared Their catalytic activity and enantioselectivity in desymmetrization reactions such as ring-closing metathesis of amines and lactams and ring-opening/cross-metathesis of substituted norborneols with styrene were compared to the results obtained with the only known alkylimido catalyst, Mo(NAd)(CHCMe₂Ph)[(S)-Biphen]. Activities and enantioselectivities provided by these new chiral complexes vary significantly, but in virtually all instances explored were not superior to the adamantylimido analogs. The crystal structure of Mo(NPhCy)(CHCMe₂Ph)[(S)-Biphen] is reported. In the experiment, the researchers used many compounds, for example, (S)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol (cas: 205927-03-3Related Products of 205927-03-3).

(S)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol (cas: 205927-03-3) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to low toxicity and inexpensive, earth-abundant. Copper nanoparticles can also catalyze the coupling reaction of phenols, thiols, xanthogenates, nitrogen-containing nucleophiles, selenium ruthenium nucleophiles and the like.Related Products of 205927-03-3

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Copper oxidation chemistry using a 19-iminopyridine-bearing steroidal ligand: (i) C5-C6 olefin difunctionalization and (ii) C1β-hydroxylation/C19-peroxidation was written by Offei, Samuel D.;Arman, Hadi D.;Yoshimoto, Francis K.. And the article was included in Steroids in 2022.Reference of 34946-82-2 This article mentions the following:

In this study, a 19-imino pyridine DHEA derivative was synthesized and was treated with copper nitrate and hydrogen peroxide. Results showed the difunctionalization of an olefin for δ-5 steroid substrates to yield a 5-β-hydroxylated 6-α-nitrate ester product. In contrast, for 19-imino pyridine precursors with a 5-α-androstane steroid backbone, a 1-β-hydroxylation and 19-peroxidation occurred to yield a 1-β-hydroxylated 19-imidoperoxoic acid product I. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Reference of 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Copper catalyst has received great attention owing to the low toxicity and low cost. Due to these characteristics, copper nanoparticles have generated a great deal of interest especially in the field of catalysis. Reference of 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Acid-mediated decarboxylative C-H coupling between arenes and O-allyl carbamates was written by Loro, Camilla;Oble, Julie;Foschi, Francesca;Papis, Marta;Beccalli, Egle M.;Giofre, Sabrina;Poli, Giovanni;Broggini, Gianluigi. And the article was included in Organic Chemistry Frontiers in 2022.Recommanded Product: 34946-82-2 This article mentions the following:

Treatment of O-allyl N-tosyl carbamates RNHC(O)OC(R₁)(R₂)(CH₂)nCH=CHR₃ (R = Ts, o-Ns; R₁ = R₂ = R₃ = H, Me; n = 0, 1) with aromatic compounds ArH (Ar = 2,4,6-trimethylphenyl, 2-methylphenyl, 1,3,5-triethylphenyl, etc.) of Cu(OTf)₂ or TMSOTf as promoters affords N-substituted 1-arylpropan-2-amines ArCH₂CH(CH₃)NHR₃, 1,2- or 1,1-diarylpropanes I, or indanes II (R₄ = R₅ = H, Me), depending on the nature of the promoter and of aryl substrates. A full mechanistic rational allowing appreciation of the outcome of these novel C-H based cascades is proposed. An initial acid promoted decarboxylative/deamidative Friedel-Crafts allylation takes place. After protonation of the allylated arene, evolution of the resulting cation may follow different paths depending on the nature of the arene partner and of the allyl moiety in the carbamate. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Recommanded Product: 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Copper catalyst has received great attention owing to the low toxicity and low cost. These ligands enable the reaction promoted in mild condition. The reaction scope has also been greatly expanded, rendering this copper-based cross-coupling attractive for both academia and industry. Recommanded Product: 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Aromatic nucleophilic substitution: A case study of the interaction of a lithiated nitronyl nitroxide with polyfluorinated quinoline-N-oxides was written by Gurskaya, Larisa;Rybalova, Tatyana;Beregovaya, Irina;Zaytseva, Elena;Kazantsev, Maxim;Tretyakov, Evgeny. And the article was included in Journal of Fluorine Chemistry in 2020.Product Details of 14781-45-4 This article mentions the following:

A 4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl lithium derivative was found to react with 5,6,7,8-tetrafluoro- or 5,7,8-trifluoro-6-(trifluoromethyl)quinoline-N-oxides with the formation of products of aromatic nucleophilic substitution of the H atom at position 2 of the quinoline ring. The reaction regioselectivity is supported by the data of quantum-chem. calculations Mol. and crystal structures of the obtained nitronyl nitroxides were solved by monocrystal X-ray diffraction anal., and the nature of the radical was ascertained by ESR spectroscopy. Heterospin complexes of Cu(hfac)₂ with the synthesized quinoline-substituted nitronyl nitroxides were prepared According to X-ray diffraction anal., seven-membered metallocycles are formed in the complexes owing to simultaneous coordination of the nitroxyl and N-oxide groups by the Cu atom. In the experiment, the researchers used many compounds, for example, copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4Product Details of 14781-45-4).

copper(ii)hexafluor-2,4-pentanedionate (cas: 14781-45-4) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to low toxicity and inexpensive, earth-abundant. Copper nanoparticles can also catalyze the coupling reaction of phenols, thiols, xanthogenates, nitrogen-containing nucleophiles, selenium ruthenium nucleophiles and the like.Product Details of 14781-45-4

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Photoredox/copper cocatalyzed domino cyclization of oxime esters with TMSCN: access to antifungal active tetrasubstituted pyrazines was written by Cao, Shujun;Yuan, Weidong;Li, Yun;Teng, Xinjie;Si, Huaxing;Chen, Rongshun;Zhu, Yingguang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Electric Literature of C2CuF6O6S2 This article mentions the following:

A photoredox/copper cocatalyzed domino cyclization of oxime esters R¹C(CH₂R²)=NOC(O)(4-CF₃C₆H₄) (R¹ = Ph, 2-thienyl, Me, etc.; R² = Ph, 1H-pyrazol-1-ylmethyl, methoxymethyl, etc.) with TMSCN has been developed. A range of structurally novel tetrasubstituted pyrazines I have been obtained. This method features high bond-forming efficiency, high step economy, broad substrate scope, and gram-scale synthesis. Moreover, preliminary bioactivity evaluation of pyrazine products I shows their promising antifungal activities. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Electric Literature of C2CuF6O6S2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Copper has continued to be one of the most utilized and important transition metal catalysts in synthetic organic chemistry. Copper nanoparticles can catalyze the Ullmann coupling reaction in a wide range of applications.Electric Literature of C2CuF6O6S2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”