Beagan, Abeer M.; Alghamdi, Ahlam A.; Lahmadi, Shatha S.; Halwani, Majed A.; Almeataq, Mohammed S.; Alhazaa, Abdulaziz N.; Alotaibi, Khalid M.; Alswieleh, Abdullah M. published an article in 2021. The article was titled 《Folic acid-terminated poly(2-diethyl amino ethyl methacrylate) brush-gated magnetic mesoporous nanoparticles as a smart drug delivery system》, and you may find the article in Polymers (Basel, Switzerland).Computed Properties of Br2Cu The information in the text is summarized as follows:
Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumor selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumor-targeted drug delivery via the folate receptor. 2-Diethyl amino Et methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by XPS. pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells. In the experiment, the researchers used many compounds, for example, Cupric bromide(cas: 7789-45-9Computed Properties of Br2Cu)
Cupric bromide(cas: 7789-45-9) can be used as reducing agent, when complexed by three molecules of pyridine initiators for the controlled polymerization of styrene, methyl acrylate and methyl methacrylate.Computed Properties of Br2Cu
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”