Category: 14898-67-0

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ruthenium(III) chloride xhydrate( cas:14898-67-0 ) is researched.Safety of Ruthenium(III) chloride xhydrate.Roy, Souvik; Mondru, Anil Kumar; Chakraborty, Tania; Das, Abhijit; Dasgupta, Sandipan published the article 《Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways》 about this compound( cas:14898-67-0 ) in Toxicology and Applied Pharmacology. Keywords: polyphenol phloretin complex ruthenium anticancer PI3K signaling breast cancer; ruthenium anticancer Akt mTOR VEGF signaling breast cancer; Antioxidant; Apoptosis; Breast carcinoma; Chemotherapeutics; DMBA; Ruthenium-phloretin complex. Let’s learn more about this compound (cas:14898-67-0).

Our recent investigation directed to synthesize a novel ruthenium-phloretin complex accompanied by the study of antioxidant in addition to DNA binding capabilities, to determine the chemotherapeutic activity against breast carcinoma in vitro and in vivo. Ruthenium-phloretin complex was synthesized and characterized by different spectroscopic methods. The complex was further investigated to determine its efficacy in both MCF-7 and MDA-MB-231 human carcinoma cell lines and finally in an in vivo model of mammary carcinogenesis induced by DMBA in rats. Our studies confirm that the chelation of the metal and ligand was materialize by the 3-OH and 9-OH functional groups of the ligand and the complex is found crystalline and was capable of intercalating with CT-DNA. The complex was capable of reducing cellular propagation and initiate apoptotic events in MCF-7 and MDA-MB-231 breast carcinoma cell lines. Ruthenium-phloretin complex could modulate p53 intervene apoptosis in the breast carcinoma, initiated by the trail of intrinsic apoptosis facilitated through Bcl2 and Bax and at the same time down regulating the PI3K/Akt/mTOR pathway coupled with MMP9 regulated tumor invasive pathways. Ruthenium-phloretin chemotherapy could interrupt, revoke or suspend the succession of breast carcinoma by altering intrinsic apoptosis along with the anti-angiogenic pathway.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Category: copper-catalyst. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ruthenium(III) chloride xhydrate, is researched, Molecular Cl3H2ORu, CAS is 14898-67-0, about Identification of a chemical fingerprint linking the undeclared 2017 release of 106Ru to advanced nuclear fuel reprocessing. Author is Cooke, Michael W.; Botti, Adrian; Zok, Dorian; Steinhauser, Georg; Ungar, Kurt R..

The undeclared release and subsequent detection of 106Ru across Europe from late Sept. to early Oct. of 2017 prompted an international effort to ascertain the circumstances of the event. While dispersion modeling, corroborated by ground deposition measurements, has narrowed possible locations of origin, there has been a lack of direct empirical evidence to address the nature of the release. This is due to the absence of radiol. and chem. signatures in the sample matrixes, considering that such signatures encode the history and circumstances of the radioactive contaminant. In limiting cases such as this, the authors introduce the use of selected chem. transformations to elucidate the chem. nature of a radioactive contaminant as part of a nuclear forensic investigation. Using established ruthenium polypyridyl chem., they have shown that a small percentage (1.2±0.4%) of the radioactive 106Ru contaminant exists in a polychlorinated Ru(III) form, partly or entirely as β-106RuCl3, while 20% is both insoluble and chem. inert, consistent with the occurrence of RuO2, the thermodn. end point of the volatile RuO4. Together, these findings present a clear signature for nuclear fuel reprocessing activity, specifically the reductive trapping of the volatile and highly reactive RuO4, as the origin of the release. Considering that the previously established 103Ru:106Ru ratio indicates that the spent fuel was unusually young with respect to typical reprocessing protocol, it is likely that this exothermic trapping process proved to be a tipping point for an already turbulent mixture, leading to an abrupt and uncontrolled release.

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Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Synthetic Route of Cl3H2ORu. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ruthenium(III) chloride xhydrate, is researched, Molecular Cl3H2ORu, CAS is 14898-67-0, about A coordinated ruthenium-rifampicin complex reprogramming the colon carcinoma micro-environment mediated by modulation of p53/AkT/mTOR/VEGF pathway. Author is Zeng, Jie; Zhao, Yu; Li, Kexun; Long, Daoling; Li, Wei; Liang, Liang.

WHO suggests that colon cancer incidences are rising steadily, propelling researchers to search for novel chemotherapeutic options. Metal-based chemotherapy is a potential forte to explore ruthenium-based complexes, exhibiting the capability to influence a variety of cellular targets. We discovered the chemotherapeutic effects of ruthenium-rifampicin complex on HT-29 and HCT-116 human colorectal cell lines and on a chem. developed murine colorectal cancer model. Complex was synthesized and characterized by anal. techniques and evaluation of antioxidant potential along with DNA binding capabilities. The complex minimizes cellular propagation and initiates apoptotic events in the colon cancer cell lines of HT-29 and HCT-116. The results of the in vivo study suggest that the complex has been successful in minimizing the wide spectrum of aberrant crypt foci and hyperplastic lesions, as well as encouraging elevated amounts of CAT, SOD and glutathione. Along with that, p53 could be modulated by the ruthenium-rifampicin complex to interfere with apoptosis in colon carcinoma, initiated by the intrinsic apoptotic trail facilitated through Bcl2 and Bax, thus controlling the Akt/mTOR/VEGF pathway coupled through the WNT/β-catenin trail. Ruthenium-rifampicin chemotherapy could interrupt, retract or interrupt the progression of colorectal cancer through modifying intrinsic apoptosis including the antiangiogenic pathway, thereby achieving the function of a potential contender in chemotherapy in the near future.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Product Details of 14898-67-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ruthenium(III) chloride xhydrate, is researched, Molecular Cl3H2ORu, CAS is 14898-67-0, about Photoexcited Electron Dynamics of Nitrogen Fixation Catalyzed by Ruthenium Single-Atom Catalysts.

It is still a grand challenge to exploit efficient catalysts to achieve sustainable photocatalytic N2 reduction under ambient conditions. Here, we developed a ruthenium-based single-atom catalyst anchored on defect-rich TiO2 nanotubes (denoted Ru-SAs/Def-TNs) as a model system for N2 fixation. The constructed Ru-SAs/Def-TNs exhibited a catalytic efficiency of 125.2μmol g-1 h-1, roughly 6 and 13 times higher than those of the supported Ru nanoparticles and Def-TNs, resp. Through ultrafast transient absorption and photoluminescence spectroscopy, we revealed the relationship between catalytic activity and photoexcited electron dynamics in such a model SA catalytic system. The unique ligand-to-metal charge-transfer state formed in Ru-SAs/Def-TNs was found to be responsible for its high catalytic activity because it can greatly promote the transfer of photoelectrons from Def-TNs to the Ru-SAs center and the subsequent capture by Ru-SAs. This work sheds light on the origin of the high performance of SA catalysts from the perspective of photoexcited electron dynamics and hence enriches the mechanistic understanding of SA catalysis.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Reference of Ruthenium(III) chloride xhydrate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ruthenium(III) chloride xhydrate, is researched, Molecular Cl3H2ORu, CAS is 14898-67-0, about Nitrogen-Doped Reduced Graphene Oxide Supported Pd4.7Ru Nanoparticles Electrocatalyst for Oxygen Reduction Reaction. Author is Park, Gil-Ryeong; Jo, Seung Geun; Varyambath, Anuraj; Kim, Jeonghyun; Lee, Jung Woo.

It is imperative to design an inexpensive, active, and durable electrocatalyst in oxygen reduction reaction (ORR) to replace carbon black supported Pt (Pt/CB). In this work, we synthesized Pd4.7Ru nanoparticles on nitrogen-doped reduced graphene oxide (Pd4.7Ru NPs/NrGO) by a facile microwave-assisted method. Nitrogen atoms were introduced into the graphene by thermal reduction with NH3 gas and several nitrogen atoms, such as pyrrolic, graphitic, and pyridinic N, found by XPS. Pyridinic nitrogen atoms acted as efficient particle anchoring sites, making strong bonding with Pd4.7Ru NPs. Addnl., carbon atoms bonding with pyridinic N facilitated the adsorption of O2 as Lewis bases. The uniformly distributed ∼2.4 nm of Pd4.7Ru NPs on the NrGO was confirmed by transmission electron microscopy. The optimal composition between Pd and Ru is 4.7:1, reaching -6.33 mA/cm2 at 0.3 VRHE for the best ORR activity among all measured catalysts. Furthermore, accelerated degradation test by electrochem. measurements proved its high durability, maintaining its initial c.d. up to 98.3% at 0.3 VRHE and 93.7% at 0.75 VRHE, whereas other catalysts remained below 90% at all potentials. These outcomes are considered that the doped nitrogen atoms bond with the NPs stably, and their electron-rich states facilitate the interaction with the reactants on the surface. In conclusion, the catalyst can be applied to the fuel cell system, overcoming the high cost, activity, and durability issues.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Reference of Ruthenium(III) chloride xhydrate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ruthenium(III) chloride xhydrate, is researched, Molecular Cl3H2ORu, CAS is 14898-67-0, about Fuelling the hydrogen economy: Scale-up of an integrated formic acid-to-power system.

Transitioning from fossil fuels to sustainable and green energy sources in mobile applications is a difficult challenge and demands sustained and highly multidisciplinary efforts in R&D. Liquid organic hydrogen carriers (LOHC) offer several advantages over more conventional energy storage solutions, but have not been yet demonstrated at scale. Herein we describe the development of an integrated and compact 25 kW formic acid-to-power system by a team of BSc and MSc students. We highlight a number of key engineering challenges encountered during scale-up of the technol. and discuss several aspects commonly overlooked by academic researchers. Conclusively, we provide a critical outlook and suggest a number of developmental areas currently inhibiting further implementation of the technol.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ruthenium(III) chloride xhydrate, is researched, Molecular Cl3H2ORu, CAS is 14898-67-0, about Luminescence quenching of tris(4,4′-dimethyl-2,2′-bipyridyl)ruthenium(II) complex with quinones in aprotic polar medium.Computed Properties of Cl3H2ORu.

The photoinduced electron transfer interaction between a luminescent metal-ligand probe, [Ru(dmbpy)3] 2+ and quinones have been investigated by absorption and fluorescence spectroscopy. The reactions of quinones with the excited state ruthenium(II) complex in DMF have been studied by luminescence quenching technique and the bimol. quenching rate constant kq values are found close to the diffusion controlled rate. The complex has an absorption maximum of 458 nm. It shows a photoluminescence at 608 nm. The lifetime of the complex in DMF is 164 ns. The ground state absorption measurements are used to confirm the nature of quenching. Transient absorption spectral measurements are performed and the oxidative nature of quenching is confirmed. The detection of semiquinone anion radical using time resolved transient absorption spectroscopy and the linear variation of log kqvs reduction potential of the quinones confirms the electron transfer nature of the reaction.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

COA of Formula: Cl3H2ORu. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ruthenium(III) chloride xhydrate, is researched, Molecular Cl3H2ORu, CAS is 14898-67-0, about Detection of Ru potential metallodrug in human urine by MALDI-TOF mass spectrometry: Validation and options to enhance the sensitivity. Author is Nunes, Nadia; Popovic, Iva; Abreu, Elder; Maciel, Dina; Rodrigues, Joao; Soto, Juan; Algarra, Manuel; Petkovic, Marijana.

We studied the possibility of detection of [Ru(η5-C5H5)(PPh3)2Cl] (abbreviated by RuCp) complex as a model system for Ru-based metallodrugs in human urine by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) without previous purification or removal of inorganic salts. Inorganic salts might prevent the detection of RuCp by MALDI-TOF MS, most likely through the increased number and intensity of background/organic matrix signals. This problem might be overcome by the acquisition of matrix-free spectra and the addition of nanoparticles, such as carbon dots, to the urine solution Our results suggest that RuCp is easily detectable by MALDI-TOF MS in all acquisition conditions, with the CHCA matrix being the best for acquisition in phosphate-containing solutions, whereas in urine, DHB and matrix-free approach demonstrated the highest sensitivity, precision, and reproducibility. The sensitivity of matrix-free MALDI detection of RuCp could be increased by the addition of carbon dots to the urine. Based on theor. calculations for all matrix/analyte combinations, the model for the interaction of RuCp with carbon dots was established, and higher sensitivity explained.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Safety of Ruthenium(III) chloride xhydrate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ruthenium(III) chloride xhydrate, is researched, Molecular Cl3H2ORu, CAS is 14898-67-0, about Decoration of Ru/RuO2 hybrid nanoparticles on MoO2 plane as bifunctional electrocatalyst for overall water splitting.

Hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) are the two branches of artificial overall water splitting (OWS), in which the reaction efficiency usually depends on different specific catalysts. Although effective bifunctional electrocatalyst for OWS (HER and OER) are highly desired, designing and constructing such suitable materials is full of challenges to overcome several difficulties, involving slow kinetics, differences in catalytic mechanisms, large overpotential values, and low round-trip efficiencies. In this work, we reported a new bifunctional electrocatalyst Ru/RuO2-MoO2 catalyst (RRMC) via a redox solid phase reaction (RSPR) strategy to achieve the high electrocatalytic activity of OWS. Briefly, due to the restricted transport behavior of atoms in solid state precursor, the designed redox reaction occurred between the adjacent part of RuO2 and MoS2, forming Ru/RuO2 hybrid NPs and MoO2 plane. Therefore, the newly formed Ru/RuO2 hybrid NPs and MoO2 plane were tightly combined and used as an electrocatalyst for OWS. Benefiting from the exposed active sites and optimized electronic structure, the RRMC sample annealed at 500°C (RRMC-500) exhibited low overpotential for HER (18 mV) and for OER (260 mV) at 10 mA cm-2 under alk. conditions. Especially, a low cell voltage of 1.54 V was required at 10 mA cm-2 under alk. condition.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Reference of Ruthenium(III) chloride xhydrate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ruthenium(III) chloride xhydrate, is researched, Molecular Cl3H2ORu, CAS is 14898-67-0, about Urea-less NOx Reduction by Carbon Monoxide in Simulated Lean-Burn Exhausts. Author is Heo, Iljeong; You, Young Woo; Lee, Jin Hee; Schmieg, Steven. J.; Yoon, Dal Young; Kim, Chang Hwan.

lean NOx after-treatment is a major barrier to widespread adoption of advanced combustion power-trains to reduce greenhouse gas and toxic exhaust emissions. urea/selective catalytic reduction (U/SCR) of NOx by NH3 generated by urea decomposition, is commonly regarded as the best way to reduce NOx in low temperature lean exhaust gas; however, the urea/SCR system has inherent drawbacks: periodic re-fill of the aqueous urea solution and complicated hardware. this work demonstrated a state-of-the-art catalyst which is extremely selective and efficiently reduces NOx, primarily with the most abundant reductant, CO, particularly in the presence of O2 (>5%) at low temperature at temperatures <250°, IrRu/Al2O3 catalysts achieved higher NOx conversion with CO only vs. a com. Cu-based urea/SCR catalyst with NH3 as primary reductant. the IrRu catalyst displayed high thermal stability and SO2 tolerance, very important factors for actual applications. In some applications, this compound(14898-67-0)Reference of Ruthenium(III) chloride xhydrate is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”