Category: copper-catalyst

As a common heterocyclic compound, it belongs to copper-catalyst compound, name is [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride, and cas is 578743-87-0, its synthesis route is as follows.,578743-87-0

In a flame-dried Schlenk tube under argon atmosphere, [CuCl(IPr)] (1) (0.3mmol, 150mg, 1 equiv.) and KCN (0.3mmol, 19mg, 1 equiv.) were introduced in degassed MeOH (5mL) and the reaction mixture was stirred under reflux (50C) for 4h. After returning to room temperature, the reaction mixture was concentrated to dryness under vacuum. The complex was then dissolved in dichloromethane and filtered through a pad of Celite and concentrated again under vacuum. A purification by recrystallization by slow diffusion of pentane in a THF solution of the complex led to the pure complex (4) as a white powder (143mg, 97% yield). 1H-NMR (CDCl3, 400MHz): delta 1.22 (d, J=6.9Hz, 12H), 1.27 (d, J=6.9Hz, 12H), 2.50 (sept, J=6.9Hz, 4H), 7.14 (s, 2H), 7.30 (d, J=7.8Hz, 4H), 7.50 (t, J=7.8Hz, 4H) ppm. (spectroscopic data in good agreement with the literature) [54].

With the complex challenges of chemical substances, we look forward to future research findings about [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride

Reference£º
Article; Elie, Margaux; Mahoro, Gilbert Umuhire; Duverger, Eric; Renaud, Jean-Luc; Daniellou, Richard; Gaillard, Sylvain; Journal of Organometallic Chemistry; vol. 893; (2019); p. 21 – 31;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belongs to copper-catalyst compound, name is [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride, and cas is 578743-87-0, its synthesis route is as follows.,578743-87-0

1) 0.2 mmol (NHC) CuCl was dissolved in 3 ml of dry THF in a 20 ml dry glass bottle to form a suspension,The glass was then placed in a glove box refrigerator and frozen at -35 C for 1 h;2) 42.3 mg (0.95 eq) [tBu3PN] Li was dissolved in 3 ml of dry THF in another 20 ml dry glass vial,And then put the glass bottle into the glove box refrigerator,Frozen at -35 C for 1 h;3) Slowly drop the [tBu3PN] Li solution of 2) in a cold (NHC) CuCl suspension in 1) with stirring,After completion of the dropwise addition, the mixture was stirred in a glove box at room temperature for 13 h;4) After completion of the reaction, the solvent (THF) was dried in vacuo to give an oily slag,Followed by the addition of 7 ml of n-pentane or n-hexane to give a suspension,And stirred at room temperature for 15 min,And then through the neutral diatomite short pad filter to remove insoluble matter,The filtrate was placed in a refrigerator and cooled at -35 C for 3-4 h,And then filtered through neutral diatomaceous earth,And then frozen the filtrate,Repeated several times to obtain a clear n-pentane or n-hexane solution,The clear solution was dried to give a white crystalline solid,Ie complex A or B.

With the complex challenges of chemical substances, we look forward to future research findings about 578743-87-0,belong copper-catalyst compound

Reference£º
Patent; Shan, Xida; Bai, Tao; Yang, Yanhui; (31 pag.)CN106243132; (2016); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7787-70-4, Copper(I) bromide. This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.7787-70-4

To a Schlenk flask containing deoxygenated absolute ethanol (50 mL) was added in the following order, the CuBr (0.19 mmol, 0.027 g) and the ligand (L) (0.38 mmol, 0.10 g). The resulting solution was stirred at room temperature for 14 h. The solution was concentrated and a white precipitate appeared. The solid obtained was filtered off, and washed with diethyl ether (5 mL) under anaerobic conditions and dried under vacuum. 5: (Yield. 82%). Anal. Calc. for C30H28CuN8O2 (596.14 amu): C, 53.30; H, 4.17; N, 16.57. Found: C, 53.56; H, 4.27; N, 16.46%. Conductivity (Omega-1 cm2 mol-1, 1.2 * 10-3 M in CH3OH): 90. IR: (KBr, cm-1): 3325 nu(O-H), 3075 nu(C-H)ar, 2941 nu(C-H)al, 1604-1566 (nu(C=C), nu(C=N))ar, 1464 (delta(C=C), delta(C=N))ar, 1098, 1086 delta(C-H)ar,ip, 765, 696 delta(C-H)ar,oop. 1H NMR: (DMSO-d6 solution, 250 MHz, 298 K) delta: 8.67/8.62 [1H/1H, d, 3J = 4.7 Hz, 3J = 4.8 Hz, Hortho/Hortho’], 8.52/8.08 [1H/1H, t, 3J = 7.3 Hz, 3J = 7.0 Hz, Hpara/Hpara’], 8.05/7.94 [1H/1H, d, 3J = 7.3 Hz, H4/H4′], 7.62 [1H, s, Hpz], 7.83/7.55 [1H/1H, m, Hmeta/Hmeta’], 4.54 [2H, t, 3J = 5.1 Hz, NCH2-CH2OH], 4.02 [2H, t, 3J = 5.1 Hz, NCH2-CH2OH], 4.02 [2H,t, 3J = 5.1 Hz, NCH2-CH2OH]. In this complex, the signal attributableto proton hydroxyl (OH) is not observed. 13C{1H] NMR:(DMSO-d6 solution, 63 MHz, 298 K) delta: 158.5/153.2 (Cortho/Cortho’),143.4/140.2 (Cpara/Cpara’), 129.3/127.2 (C4/C40), 126.1/123.4 (Cmeta/Cmeta’), 108.2 (Cpz), 64.5, (NCH2-CH2OH), 58.6 (NCH2-CH2OH)ppm. ESI(+)(m/z) (%) = 596 (100%) [Cu(L)2]+.

7787-70-4 Copper(I) bromide 24593, acopper-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Guerrero, Miguel; Calvet, Teresa; Font-Bardia, Merce; Pons, Josefina; Polyhedron; vol. 119; (2016); p. 555 – 562;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.578743-87-0,[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride,as a common compound, the synthetic route is as follows.,578743-87-0

In a dry double-mouth bottle to place Pt – 3 (0.0594 g, 0.1 mmol), CuClNHC (0.0488 g, 0.1 mmol), vacuum pumping and nitrogen cycle three times, then the nitrogen flow by adding 10 ml ethanol, stirring reflux reaction for 4 hours, cooling to room temperature, then added potassium hexafluorophosphate (0.184 g, 1 mmol), stirring at the room temperature reaction 2 hours, filtered, concentrated filtrate, ethanol: dichloromethane=1:10 column, get the orange solid 0.047 g, and the yield is 40%.

578743-87-0 [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride 0, acopper-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Jiangsu University Of Science And Technology; Shi Chao; Li Qiuxia; Zhang Xinghua; (24 pag.)CN108690096; (2018); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO151,mainly used in chemical industry, its synthesis route is as follows.,34946-82-2

A methanolic solution of ligand trans-cyclohexane-1,2-diamine(0.1142 g, 1 mmol) was added dropwise to a clear solution ofCopper(II) trifluoromethanesulfonate (0.1808 g, 0.5 mmol) inmethanol (10 mL). The resultant solution was stirred at roomtemperature for 6 h to produce a dark blue coloured solution. Thediffraction quality crystals of the titled complex were obtaineddirectly by slow evaporation of the deep bluish methanolic solutionat room temperature. Yield: 0.272 g, 75%, m.p: 258 C, Anal. Calc. forC14H32CuF6N4O8S2: C, 26.86; H, 5.15; N, 8.95. Found: C, 26.54; H,5.32, N, 8.78. Selected FT-IR (KBr), cm1: n(NH2) 3332e3279, n(CH2)2967e2861, n(OH) 3463, n(CueN) 628, n(CueO) 514. UVeVis [lmax(nm), epsilon (L mol1 cm1)]: 243 (8940), 548 (89).

With the complex challenges of chemical substances, we look forward to future research findings about Copper(II) trifluoromethanesulfonate,belong copper-catalyst compound

Reference£º
Article; Agrahari, Bhumika; Layek, Samaresh; Kumari, Shweta; Anuradha; Ganguly, Rakesh; Pathak, Devendra D.; Journal of Molecular Structure; vol. 1134; (2017); p. 85 – 90;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belong copper-catalyst compound,5,10,15,20-Tetraphenyl-21H,23H-porphine copper(II),14172-91-9,Molecular formula: C44H30CuN4,mainly used in chemical industry, its synthesis route is as follows.,14172-91-9

General procedure: To a solution of corresponding porphyrin, the copper complex(1.13 mmol) in methylene chloride (90 mL) Cu(NO3)2¡¤3H2O(2.30 mmol) in the mixture of acetic acid (5 mL) and acetic anhydride (2 mL) was added, and reaction mixture was stirred for 3 h at room temperature, with TLC monitoring (CHCl3-hexane 1:2). After completion of the reaction the solution was washed with water (200 mL), then with Na2CO3 solution, and the organic phase was separated and dried over Na2SO4. After removal of the solvent under reduced pressure, the residue was purified by column chromatography on silica gel using a CH2Cl2-hexane system (3:7).

With the synthetic route has been constantly updated, we look forward to future research findings about 5,10,15,20-Tetraphenyl-21H,23H-porphine copper(II),belong copper-catalyst compound

Reference£º
Article; Ol’shevskaya, Valentina A.; Alpatova, Viktoriya M.; Radchenko, Alexandra S.; Ramonova, Alla A.; Petrova, Albina S.; Tatarskiy, Victor V.; Zaitsev, Andrei V.; Kononova, Elena G.; Ikonnikov, Nikolay S.; Kostyukov, Alexey A.; Egorov, Anton E.; Moisenovich, Mikhail M.; Kuzmin, Vladimir A.; Bragina, Natalya A.; Shtil, Alexander A.; Dyes and Pigments; vol. 171; (2019);,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Copper(I) bromide, A common heterocyclic compound, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 7787-70-4

To a Schlenk flask containing deoxygenated absolute ethanol (50 mL) was added in the following order, the CuBr (0.19 mmol, 0.027 g) and the ligand (L) (0.38 mmol, 0.10 g). The resulting solution was stirred at room temperature for 14 h. The solution was concentrated and a white precipitate appeared. The solid obtained was filtered off, and washed with diethyl ether (5 mL) under anaerobic conditions and dried under vacuum. 5: (Yield. 82%). Anal. Calc. for C30H28CuN8O2 (596.14 amu): C, 53.30; H, 4.17; N, 16.57. Found: C, 53.56; H, 4.27; N, 16.46%. Conductivity (Omega-1 cm2 mol-1, 1.2 * 10-3 M in CH3OH): 90. IR: (KBr, cm-1): 3325 nu(O-H), 3075 nu(C-H)ar, 2941 nu(C-H)al, 1604-1566 (nu(C=C), nu(C=N))ar, 1464 (delta(C=C), delta(C=N))ar, 1098, 1086 delta(C-H)ar,ip, 765, 696 delta(C-H)ar,oop. 1H NMR: (DMSO-d6 solution, 250 MHz, 298 K) delta: 8.67/8.62 [1H/1H, d, 3J = 4.7 Hz, 3J = 4.8 Hz, Hortho/Hortho’], 8.52/8.08 [1H/1H, t, 3J = 7.3 Hz, 3J = 7.0 Hz, Hpara/Hpara’], 8.05/7.94 [1H/1H, d, 3J = 7.3 Hz, H4/H4′], 7.62 [1H, s, Hpz], 7.83/7.55 [1H/1H, m, Hmeta/Hmeta’], 4.54 [2H, t, 3J = 5.1 Hz, NCH2-CH2OH], 4.02 [2H, t, 3J = 5.1 Hz, NCH2-CH2OH], 4.02 [2H,t, 3J = 5.1 Hz, NCH2-CH2OH]. In this complex, the signal attributableto proton hydroxyl (OH) is not observed. 13C{1H] NMR:(DMSO-d6 solution, 63 MHz, 298 K) delta: 158.5/153.2 (Cortho/Cortho’),143.4/140.2 (Cpara/Cpara’), 129.3/127.2 (C4/C40), 126.1/123.4 (Cmeta/Cmeta’), 108.2 (Cpz), 64.5, (NCH2-CH2OH), 58.6 (NCH2-CH2OH)ppm. ESI(+)(m/z) (%) = 596 (100%) [Cu(L)2]+.

With the rapid development of chemical substances, we look forward to future research findings about Copper(I) bromide

Reference£º
Article; Guerrero, Miguel; Calvet, Teresa; Font-Bardia, Merce; Pons, Josefina; Polyhedron; vol. 119; (2016); p. 555 – 562;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact.7787-70-4, Copper(I) bromide it is a common compound, a new synthetic route is introduced below.7787-70-4

CuI (0.190 g, 1 mmol) was dissolved in acetonitrile (6 ml)at room temperature, followed by the addition of a solution of Hdpt (0.112 g, 0.5 mmol) in acetonitrile (8 ml) with vigorous magnetic stirring in a 25 ml Parr Teflon-lined stainless steel vessel. The mixture was heated for 3 days at 150 C and then cooled to room temperature at a rate of10 C/h.

With the rapid development of chemical substances, we look forward to future research findings about Copper(I) bromide

Reference£º
Article; Hu, Sheng; Lin, DianRong; Xie, ZhenMing; Zhou, ChangXia; He, WenXi; Yu, FangYong; Transition Metal Chemistry; vol. 40; 6; (2015); p. 623 – 629;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

7787-70-4, A common heterocyclic compound, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route., 7787-70-4

A dry and Ar-flushed Schlenk flask was charged with P(OEt)3 (5.2 mL, 30.0 mmol) in benzene (30 mL). CuBr (4.3 g, 30.0 mmol) was added. After the mixture had stirred at r.t. for 1 h and at 80 C for 1 h, unsolved solid was removed by filtration under Ar atmosphere and solvents were evaporated from the filtrate. The resulted mixture was cooled down to -78 C and was washed with n-hexane (2*). The remained solid was dried under vacuum; this gave CuBr*P(OEt)3. Yield: 6.8 g (73%); a mixture of oil and solid.

With the rapid development of chemical substances, we look forward to future research findings about Copper(I) bromide

Reference£º
Article; Moriya, Kohei; Schwaerzer, Kuno; Karaghiosoff, Konstantin; Knochel, Paul; Synthesis; vol. 48; 19; (2016); p. 3141 – 3154;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact.6046-93-1, Copper(II) acetate hydrate it is a common compound, a new synthetic route is introduced below., 6046-93-1

A mixed solvent of 75 ml of chlorobenzene and 50 ml of N,N-dimethylformamide (DMF) was added to a 250 ml three-neck distillation flask. Add 5,10,15,20-tetraphenylporphyrin (H2TPP) (0.50 g, 0.81 mmol) start stirring, after the solid is dissolved, add an appropriate amount of copper acetate monohydrate (Cu(OAc)2*H2O) (0.324 g 1.62 mmol). Put about 3g of potassium carbonate (K2CO3) in the alkali storage chamber, the mixture in the reaction kettle was heated to 150 C and kept under reflux. The progress of the reaction (UV-Vis) is monitored by thin layer chromatography (TLC) or ultraviolet visible absorption spectroscopy until the complete reaction of H2TPP is completed. The solvent is distilled off under vacuum. The remaining solid was dissolved in 150 ml of chloroform. Wash three times with 50 ml of water each time, then collect these liquids in a static layer. The organic layer was further washed three times with 50 ml of saturated sodium bicarbonate solution. Then dried with potassium sulfate (K2SO4), The solvent is distilled off under vacuum. The remaining solid was recrystallized from chloroform/heptane. A purple crystalline solid product of 0.526 g was obtained in a yield of 96%.

6046-93-1, 6046-93-1 Copper(II) acetate hydrate 165397, acopper-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Guangzhou Lvying Environmental Protection Technology Co., Ltd.; Yao Shu; Chen Liangming; Qiao Nasen¡¤wudong; (8 pag.)CN109651381; (2019); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”