The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 16606-55-6, Name is (R)-4-Methyl-1,3-dioxolan-2-one, SMILES is O=C1OC[C@@H](C)O1, in an article , author is Zhao, Xiao-Jing, once mentioned of 16606-55-6, Name: (R)-4-Methyl-1,3-dioxolan-2-one.
Enantioselective Synthesis of 3,3 ‘-Disubstituted 2-Amino-2 ‘-hydroxy-1,1 ‘-binaphthyls by Copper-Catalyzed Aerobic Oxidative Cross-Coupling
A challenging direct asymmetric catalytic aerobic oxidative cross-coupling of 2-naphthylamine and 2-naphthol, using a novel Cu-I/SPDO system, has been successfully developed for the first time. Enantioenriched 3,3 ‘-disubstituted NOBINs were achieved and could be readily derived to divergent chiral ligands and catalysts. This reaction features high enantioselectivities (up to 96 % ee) and good yields (up to 80 %). The DFT calculations suggest that the F-H interactions between CF3 of L17 and H-1,8 of 2-naphthol, and the pi-pi stacking between the two coupling partners could play vital roles in the enantiocontrol of this cross-coupling reaction.
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Reference:
Copper catalysis in organic synthesis – NCBI,
,Special Issue “Fundamentals and Applications of Copper-Based Catalysts”