In 2022,Swain, Sharada Prasanna; Kumar, K. Naveen; Mhate, Mouzma; Panchami, Hirave; Ravichandiran, V. published an article in Molecular Catalysis. The title of the article was 《Copper (II) bromide catalysed one pot bromination and amination for the green, cost-effective synthesis of clopidogrel》.Electric Literature of Br2Cu The author mentioned the following in the article:
Copper (II) bromide catalyzed one pot α-bromination and followed by amination of a benzylic ester was reported. The α-bromination of ester by copper (II) bromide generated copper (I) bromide and HBr. The copper (I) bromide was oxidized to copper (II) bromide by N-Methylmorpholine-N-Oxide (NMO) in presence of HBr. The amines undergo nucleophilic substitution reaction with α-brominated ester compound This methodol. was applied for the synthesis of the familiar antiplatelet drug clopidogrel. This green process is an alternate to classical methods for the synthesis of clopidogrel, which required, generated stochiometric amount of brominating agents and HBr, resp. In the experimental materials used by the author, we found Cupric bromide(cas: 7789-45-9Electric Literature of Br2Cu)
Cupric bromide(cas: 7789-45-9) can be used as reducing agent, when complexed by three molecules of pyridine initiators for the controlled polymerization of styrene, methyl acrylate and methyl methacrylate.Electric Literature of Br2Cu
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”