Tag: 361.6842

Copper-Catalyzed, N-Directed Distal C(sp³)-H Functionalization toward Azepanes was written by Yang, Jia-Wen;Tan, Guang-Qiang;Liang, Kai-Cheng;Xu, Ke-Dong;Su, Ma;Liu, Feng. And the article was included in Organic Letters in 2022.Related Products of 34946-82-2 This article mentions the following:

A copper-catalyzed formal [5 + 2] aza-annulation of N-fluorosulfonamides and 1,3-dienes/1,3-enynes for synthesis of structurally diverse alkene/alkyne-containing azepanes such as I [R¹ = H, Me, Et; R² = Me, Et; R¹R² = (CH²)₄, (CH²)₅; R³ = H, Me; R⁴ = Ph, n-hexyl, 4-MeC₆H₄, etc.; Ar = Ph, 4-MeOC₆H₄, 2-thienyl, etc.] and II [Ar¹ = Ph, 4-ClC₆H₄, 4-MeC₆H₄, etc.; Ar = Ph, 4-phenylphenyl, 4-MeC₆H₄, 4-BrC₆H₄, 4-MeOC₆H₄] was reported. The reaction features selective functionalization of distal unactivated C(sp³)-H bonds and a broad substrate scope, thus allowing the late-stage modification of pharmaceuticals and natural products. A radical mechanism involving 1,5-hydrogen atom transfer of N-radicals, facile coupling of alkyl radicals with 1,3-dienes/1,3-enynes, and the construction of azepane motifs via C-N bond formation was proposed. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Related Products of 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Copper catalyst has received great attention owing to the low toxicity and low cost. These ligands enable the reaction promoted in mild condition. The reaction scope has also been greatly expanded, rendering this copper-based cross-coupling attractive for both academia and industry. Related Products of 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Total synthesis of himastatin was written by D’Angelo, Kyan A.;Schissel, Carly K.;Pentelute, Bradley L.;Movassaghi, Mohammad. And the article was included in Science (Washington, DC, United States) in 2022.Application of 34946-82-2 This article mentions the following:

The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound’s biogenesis. Combining this approach with a modular synthesis enabled expedient access to more than a dozen designed derivatives of himastatin, including synthetic probes that provide insight into its antibiotic activity. The synthesis and study of antibiotic natural products with unique structures and mechanisms of action represents a proven strategy to combat the public health crisis posed by antibiotic-resistant bacteria. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Application of 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The evolution of transition metal catalysts has attained a stage of civilization that authorizes for an extensive scope of chemical bonds formation partners to be combined efficiently. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.Application of 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Cu-Catalyzed Intermolecular γ-Site C-H Amination of Cyclohexenone Derivatives: The Benefit of Bifunctional Ligands was written by Zhao, Xin;Yang, Fang;Zou, Shao-Yu;Zhou, Qian-Qian;Chen, Zi-Sheng;Ji, Kegong. And the article was included in ACS Catalysis in 2022.Recommanded Product: 34946-82-2 This article mentions the following:

Utilizing 1,10-phenanthroline-type bifunctional ligands, an efficient Cu-catalyzed intermol. site-selective remote C-H amination using cyclohexenone derivatives and anilines was realized. The amide group installed on the bifunctional ligand played a key role in stabilizing the N-centered radical generated in-situ to realize C-N-directed formation. Meanwhile, a useful catalytic system for site-selective intermol. remote γ-C-H amination to p-aminophenols and γ-aminated enones was established. This economical and practical approach using oxygen as the terminal oxidant was mild and environmentally friendly. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Recommanded Product: 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to the earth-abundant, inexpensive and low toxicity. These ligands enable the reaction promoted in mild condition. The reaction scope has also been greatly expanded, rendering this copper-based cross-coupling attractive for both academia and industry. Recommanded Product: 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Construction of substituted pyrazolo[4,3-c]quinolines via [5+1] cyclization of pyrazole-arylamines with alcohols/amines in one pot was written by Tang, Dong;Mu, Yangxiu;Iqbal, Zafar;He, Lili;Jiang, Rui;Hou, Jing;Yang, Zhixiang;Yang, Minghua. And the article was included in Journal of Heterocyclic Chemistry in 2022.Quality Control of Copper(II) trifluoromethanesulfonate This article mentions the following:

An efficient protocol had been developed for the synthesis of pyrazolo[4,3-c]quinoline derivatives I [R¹ = Me, Ph, 3-pyridyl, etc.; R² = Ph, 4-MeC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 4-NCC₆H₄; R³ = Ph, 1-naphthyl, 2-thienyl, etc.], by reacting (1H-pyrazol-5-yl)anilines and readily available alcs./amines. A wide range of substrates with diverse functional groups were smoothly converted to the corresponding products in moderate to good yields, under optimal reaction conditions. Furthermore, the strategy also proceeded well with thiol and amino acid to access pyrazolo[4,3-c]quinoline derivatives In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Quality Control of Copper(II) trifluoromethanesulfonate).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to low toxicity and inexpensive, earth-abundant. Due to these characteristics, copper nanoparticles have generated a great deal of interest especially in the field of catalysis. Quality Control of Copper(II) trifluoromethanesulfonate

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Copper/Iodine-Catalyzed Hydroxyamination of Alkenyl Keto Oximes Using DMSO as the Oxygen Atom Source and Medium was written by Yin, Xiao-Qiu;Deng, Wei;Xiang, Jian-Nan. And the article was included in European Journal of Organic Chemistry in 2022.Quality Control of Copper(II) trifluoromethanesulfonate This article mentions the following:

A new copper/I2-catalyzed hydroxyamination of alkenes of unsaturated keto oximes with DMSO as the hydroxy oxygen atom source and medium for assembling 2-(2-hydroxyalkyl)-3,4-dihydro-2H-pyrrole 1-oxides is described. Mechanistic studies suggest that the reaction is terminated by a single electron oxidation and subsequent nucleophilic reaction. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Quality Control of Copper(II) trifluoromethanesulfonate).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents belong to the most important cross-coupling reaction in organic synthesis. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.Quality Control of Copper(II) trifluoromethanesulfonate

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Direct N-Me Aziridination of Enones was written by Jat, Jawahar L.;Yadav, Ajay K.;Pandey, Chandra Bhan;Chandra, Dinesh;Tiwari, Bhoopendra. And the article was included in Journal of Organic Chemistry.Electric Literature of C2CuF6O6S2 This article mentions the following:

The first direct general method for N-Me aziridination of electron-deficient olefins, enones, was described using N-methyl-O-tosylhydroxylamine as the aminating agent in the presence of Cu(OTf)₂ catalyst. The aziridination of vinyl ketones, hitherto unknown for N-Me as well as N-H, was achieved efficiently. The open-flask reaction was stereospecific, operationally simple and additive-free. It also affords N-H aziridinated products under a similar reaction condition efficiently. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Electric Literature of C2CuF6O6S2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to the earth-abundant, low toxicity and inexpensive. The copper-mediated C-C, C-O, C-N, and C-S bond formation is a part of one oldest reaction, emphasizing the Ullmann cross-coupling reaction.Electric Literature of C2CuF6O6S2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Copper-Catalyzed Stereoselective Radical Phosphono-hydrazonation of Alkynes was written by Ogundipe, Olukayode Olamiji;Shoberu, Adedamola;Zou, Jian-Ping. And the article was included in Journal of Organic Chemistry in 2022.Quality Control of Copper(II) trifluoromethanesulfonate This article mentions the following:

A Cu-catalyzed stereoselective phosphono-hydrazonation of terminal alkynes with alkyl carbazates and diarylphosphine oxides is described. This methodol. provides facile access to a variety of β-hydrazonophosphine oxides in satisfactory yields. The reaction proceeds under mild conditions and exhibits good functional group tolerance. A mechanism featuring persulfate-mediated oxidative generation of phosphinoyl radicals and Cu-assisted hydrazonation is proposed. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Quality Control of Copper(II) trifluoromethanesulfonate).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Copper has continued to be one of the most utilized and important transition metal catalysts in synthetic organic chemistry. Due to these characteristics, copper nanoparticles have generated a great deal of interest especially in the field of catalysis. Quality Control of Copper(II) trifluoromethanesulfonate

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

8-(Methyltosylaminoethynyl)-1-naphthyl (MTAEN) Glycosides: Potent Donors in Glycosides Synthesis was written by Zhou, Si-Yu;Hu, Xin-Ping;Liu, Hui-Juan;Zhang, Qing-Ju;Liao, Jin-Xi;Tu, Yuan-Hong;Sun, Jian-Song. And the article was included in Organic Letters in 2022.Safety of Copper(II) trifluoromethanesulfonate This article mentions the following:

With 8-(methyltosylaminoethynyl)-1-naphthyl (MTAEN) glycoside as donors, a novel and efficient glycosylation protocol has been established. The MTAEN glycosylation protocol exhibits the merits of shelf-stable donors, mild catalytic promotion conditions, considerably extended substrate scope encompassing both free alcs., silylated alcs., nucleobases, primary amides, and C-type nucleophile acceptors, and applicability to various one-pot strategies for highly efficient synthesis of oligosaccharides, such as orthogonal one-pot, single-catalyst one-pot, and acceptor reactivity-controlled one-pot strategies. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Safety of Copper(II) trifluoromethanesulfonate).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The evolution of transition metal catalysts has attained a stage of civilization that authorizes for an extensive scope of chemical bonds formation partners to be combined efficiently. Copper nanoparticles can catalyze the Ullmann coupling reaction in a wide range of applications.Safety of Copper(II) trifluoromethanesulfonate

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Chemicals from lignin by diol-stabilized acidolysis: reaction pathways and kinetics was written by Zhang, Zhenlei;Lahive, Ciaran W.;Winkelman, Jozef G. M.;Barta, Katalin;Deuss, Peter J.. And the article was included in Green Chemistry in 2022.Related Products of 34946-82-2 This article mentions the following:

The product selectivity, production rates and the required process conditions are important for technol. development. Selective lignin depolymerization on the prime β-O-4 motif provides an opportunity to obtain valuable functionalized phenolic monomers. Diol-stabilized acidolysis of lignin with sulfuric acid, triflic acid or triflate salts is a proven β-O-4 cleavage methodol. that forms acetals by trapping of released reactive aldehydes. For future scale-up, a better understanding of the prime reaction pathways and how these can be controlled upon changing reaction parameters is required. By using β-O-4 model compounds and ytterbium(III) triflate as catalyst, starting material conversion and product formation including two key intermediates, the diol adducts (in this study, ethylene glycol as the diol) and the vinyl ethers, were accurately monitored, allowing for detailed kinetic modeling. Over the selected temperature range (80-150°C), higher temperatures led to higher overall carbon balance and selectivity for the main desired acetal product. The kinetic modeling allowed for establishing a detailed reaction network with activation energies and rate constants These collectively led to new insights into the key steps involved in the diol-stabilized β-O-4 motif acidolysis and how the reaction selectivity can be manipulated by controlling the reaction temperature, and the ethylene glycol and water content. Al. The elucidation on reaction kinetics and networks constitutes a further step in the design of a diol-stabilized lignin acidolysis process. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Related Products of 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Copper catalyst has received great attention owing to the low toxicity and low cost. These ligands enable the reaction promoted in mild condition. The reaction scope has also been greatly expanded, rendering this copper-based cross-coupling attractive for both academia and industry. Related Products of 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Metallo-Supramolecular Octahedral Cages with Three Types of Chirality towards Spontaneous Resolution was written by Xu, Chen;Lin, Quanjie;Shan, Chuan;Han, Xin;Wang, Hao;Wang, Heng;Zhang, Wenjing;Chen, Zhi;Guo, Chenxing;Xie, Yinghao;Yu, Xiujun;Song, Bo;Song, Heng;Wojtas, Lukasz;Li, Xiaopeng. And the article was included in Angewandte Chemie, International Edition in 2022.COA of Formula: C2CuF6O6S2 This article mentions the following:

Chirality is one of the most important intrinsic properties of (supra)mols. In this study, the authors obtained enantiomeric metallo-supramol. octahedra without using any chiral sources. Such cages were self-assembled by prochiral trispyridine ligand L , L = 2,7,12-tri(3-pyridyl)-5,5′,10,10′,15,15′-hexaethyltruxene, based on a C3h truxene core and Cu^II salts. Crystallization of the cages with BF₄^– as counterions afforded racemate crystals; while crystallizations of cages with ClO₄^– and OTf^– as counterions resulted in conglomerates with spontaneous resolution Three types of chirality were observed in each cage, including planar chirality of the truxene core, axial chirality from the pyridyl and truxene moieties, and propeller chirality of the pyridyl-Cu^II coordination sites. The cages reported here are among the largest discrete synthetic metallo-supramols. ever reported with chiral self-sorting behavior. Remarkably, the chiral cages exhibited very slow racemization even at low concentrations, suggesting their high stability in solution In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2COA of Formula: C2CuF6O6S2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents belong to the most important cross-coupling reaction in organic synthesis. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.COA of Formula: C2CuF6O6S2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”