Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7787-70-4,Copper(I) bromide,as a common compound, the synthetic route is as follows.

7787-70-4, General procedure: [CuBr(CNR)3] (1-4). Any one of the isocyanides CNR (R=Xyl, 2-Cl-6-MeC6H3, 2-Naphtyl, Cy) (3.1mmol) was added to a suspension of CuBr (143mg, 1.0mmol) in chloroform (5mL) and the reaction mixture was stirred at RT for 1h. The solvent was removed in vacuo and the product was recrystallized by slow concentration of a CH2Cl2/hexane solution at RT to give colorless (1, 2, and 4) or orange (3) crystalline solid.

As the paragraph descriping shows that 7787-70-4 is playing an increasingly important role.

Reference£º
Article; Melekhova, Anna A.; Novikov, Alexander S.; Luzyanin, Konstantin V.; Bokach, Nadezhda A.; Starova, Galina L.; Gurzhiy, Vladislav V.; Kukushkin, Vadim Yu.; Inorganica Chimica Acta; vol. 434; (2015); p. 31 – 36;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

7787-70-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7787-70-4,Copper(I) bromide,as a common compound, the synthetic route is as follows.

General procedure: The complexes were prepared according to the following method [14]: 1mmol of copper(I) bromide or copper(I) chloride is stirred in methanol until complete dissolution. Then, 2.1mmol of the corresponding phosphine ligand was added. The mixture was stirred at 60C for 30min. under nitrogen atmosphere. A microcrystalline precipitate was obtained by concentration of the solution at reduced pressure. The solid product was dissolved in a dichloromethane/methanol mixture and the solution was gradually cooled to 4C to give an air stable and colorless crystalline solid suitable for X-ray single-crystal diffraction studies.

7787-70-4 Copper(I) bromide 24593, acopper-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Espinoza, Sully; Arce, Pablo; San-Martin, Enrique; Lemus, Luis; Costamagna, Juan; Farias, Liliana; Rossi, Miriam; Caruso, Francesco; Guerrero, Juan; Polyhedron; vol. 85; (2014); p. 405 – 411;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Name is Copper(I) bromide, as a common heterocyclic compound, it belongs to copper-catalyst compound, and cas is 7787-70-4, its synthesis route is as follows.,7787-70-4

General procedure: An acetonitrile solution (5 mL) of cuprous chloride (0.008 g,0.084 mmol) was introduced dropwise to a solution of 1(0.040 g, 0.084 mmol) in dichloromethane (5 mL). The reactionwas allowed to stir at room temperature for 6 h. Afterthat, solvent was evaporated under vacuum to give microcrystallineproduct of 5 as a white solid.

With the complex challenges of chemical substances, we look forward to future research findings about Copper(I) bromide

Reference£º
Article; Kumar, Saurabh; Balakrishna, Maravanji S; Journal of Chemical Sciences; vol. 129; 8; (2017); p. 1115 – 1120;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO48,mainly used in chemical industry, its synthesis route is as follows.,7787-70-4

To a solution of CuBr (0.0135 g, 0.094 mmol) in 10 mL of acetonitrile was added dropwise 1 (0.03 g, 0.094 mmol) in dichloromethane (5 mL) at room temperature. The reaction mixture was stirred for 4 h. The solvent was removed under reduced pressure to get 6 as a pale yellow solid. Analtyically pure product of 6 was obtained by recrystallizing the crude product in a 1:2 mixture of dichloromethane and petroleum ether. Yield: 81% (0.035 g). Mp: 158-160 C. Anal. Calc. for C42H44Cu2Br2N2P2: C, 54.66; H, 4.80; N, 3.03. Found: C, 54.95; H, 4.85; N, 2.88%. 1H NMR (400 MHz, CDCl3): delta 7.52-6.83 (m, Ar, 28H), 3.50 (s, CH2, 4H), 2.42 (s, NMe2, 12H). 31P{1H} NMR (162 MHz, CDCl3): delta -16.2 (br s). MS (EI): m/z 845.22 [M-Br]+.

With the synthetic route has been constantly updated, we look forward to future research findings about Copper(I) bromide,belong copper-catalyst compound

Reference£º
Article; Ananthnag, Guddekoppa S.; Edukondalu, Namepalli; Mague, Joel T.; Balakrishna, Maravanji S.; Polyhedron; vol. 62; (2013); p. 203 – 207;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

7787-70-4, Copper(I) bromide is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7787-70-4, General procedure: [CuBr(CNR)3] (1-4). Any one of the isocyanides CNR (R=Xyl, 2-Cl-6-MeC6H3, 2-Naphtyl, Cy) (3.1mmol) was added to a suspension of CuBr (143mg, 1.0mmol) in chloroform (5mL) and the reaction mixture was stirred at RT for 1h. The solvent was removed in vacuo and the product was recrystallized by slow concentration of a CH2Cl2/hexane solution at RT to give colorless (1, 2, and 4) or orange (3) crystalline solid.

The synthetic route of 7787-70-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Melekhova, Anna A.; Novikov, Alexander S.; Luzyanin, Konstantin V.; Bokach, Nadezhda A.; Starova, Galina L.; Gurzhiy, Vladislav V.; Kukushkin, Vadim Yu.; Inorganica Chimica Acta; vol. 434; (2015); p. 31 – 36;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7787-70-4,Copper(I) bromide,as a common compound, the synthetic route is as follows.

7787-70-4, Copper(I) bromide was treated with 3 equiv of triphenylphosphine in methanol. The mixture was stirred for 4-5 h, and the pale yellow solid was filtered off and dried. Yield of Cu(PPh3)3Br 90%.

The synthetic route of 7787-70-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Saeed; Larik; Jabeen; Mehfooz; Ghumro; El-Seedi; Ali; Channar; Ashraf; Russian Journal of General Chemistry; vol. 88; 3; (2018); p. 541 – 550;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belong copper-catalyst compound,Copper(I) bromide,7787-70-4,Molecular formula: BrCu,mainly used in chemical industry, its synthesis route is as follows.,7787-70-4

General procedure: [CuBr(CNR)3] (1-4). Any one of the isocyanides CNR (R=Xyl, 2-Cl-6-MeC6H3, 2-Naphtyl, Cy) (3.1mmol) was added to a suspension of CuBr (143mg, 1.0mmol) in chloroform (5mL) and the reaction mixture was stirred at RT for 1h. The solvent was removed in vacuo and the product was recrystallized by slow concentration of a CH2Cl2/hexane solution at RT to give colorless (1, 2, and 4) or orange (3) crystalline solid.

With the synthetic route has been constantly updated, we look forward to future research findings about Copper(I) bromide,belong copper-catalyst compound

Reference£º
Article; Melekhova, Anna A.; Novikov, Alexander S.; Luzyanin, Konstantin V.; Bokach, Nadezhda A.; Starova, Galina L.; Gurzhiy, Vladislav V.; Kukushkin, Vadim Yu.; Inorganica Chimica Acta; vol. 434; (2015); p. 31 – 36;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belong copper-catalyst compound,Copper(I) bromide,7787-70-4,Molecular formula: BrCu,mainly used in chemical industry, its synthesis route is as follows.,7787-70-4

General procedure: A solution of cuprous chloride (5.8 mg, 0.058 mmol) in acetonitrile(10 mL) was added dropwise to a well stirred solution of 1(30 mg, 0.058 mmol) in dichloromethane (10 mL) at room temperaturewith constant stirring. After stirring for 6 h, the solvent wasremoved under reduced pressure and the residue obtained wasfurther washed with petroleum ether to give 4 as white solid product.Yield

With the synthetic route has been constantly updated, we look forward to future research findings about Copper(I) bromide,belong copper-catalyst compound

Reference£º
Article; Bhat, Sajad A.; Mague, Joel T.; Balakrishna, Maravanji S.; Inorganica Chimica Acta; vol. 443; (2016); p. 243 – 250;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

7787-70-4, Copper(I) bromide is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7787-70-4, 2-(Carboxy-5-nitrophenyl)malonic acid dimethyl ester (8) A solution of 2-chloro-4-nitrobenzoic acid (75 g, 372 mmol) in dimethyl malonate (900 mL) was perfused with nitrogen for 15 min. Sodium methoxide (48.3 g, 894 mmol) was added in one portion and the contents exothermed to 48 C. Fifteen minutes later, copper (I) bromide (5.4 g, 37 mmol) was added in one portion and the contents were heated to 70 C. for 24 hrs. The reaction, which was 70% complete as determined by NMR, was subsequently heated to 85 C. for 5 hrs to completely consume the remaining 2-chloro4-nitrobenzoic acid. Water (900 mL) was added to the cooled reaction followed by hexanes (900 mL). The aqueous layer was separated, toluene (900 mL) was added, the mixture was filtered and aqueous layer separated. Fresh toluene (1800 mL) was added to the aqueous layer and the biphasic mixture acidified with 6N aqueous HCl (90 mL). A white precipitate formed and the contents were stirred for 18 hrs. The product was filtered off and dried to give a white solid (78.1 g, 70%) mp 153 C. 1 H NMR (DMSO) delta8.37 (d, J=2 Hz, 1H), 8.30 (d, J=1 Hz, 2H), 5.82 (s, 1H), 3.83 (s, 6H). 13 C NMR (DMSO) delta168.0, 167.3, 149.4, 137.1, 135.8, 132.5, 125.4, 123.7, 54.5, 53.4. Anal. Calcd for C11 H10 NO8: C, 48.49; H, 3.73; N, 4.71. Found: C, 48.27; H, 3.72; N, 4.76.

The synthetic route of 7787-70-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US6121283; (2000); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7787-70-4,Copper(I) bromide,as a common compound, the synthetic route is as follows.

7787-70-4, In a round bottom flask, copper(I) bromide (0.3mmol, 0.043g) was dissolved in 5mL of degassed MeCN. Under continuous stirring and in a N2-atmosphere, a 2mL degassed NCMe solution of HC(3,5-Me2pz)3 (0.33mmol, 0.1g) was added dropwise. The mixture was stirred at room temperature for 3h, then its volume was reduced to ca. 2mL by evaporation. Hexane (10mL) was added, and the obtained precipitate was filtered off and recrystallized from a mixture if CH2Cl2 and hexane (1:1) to afford complexes 3 as off-white powder. [CuBr(Tpm*)] (3): Yield (108.9mg) 82%. Elemental analysis calcd (%) for C16H22BrCuN6: C 43.49, H 5.02, N 19.02; found: C 43.45, H 5.51, N 19.62. FTIR (KBr): nu (cm-1)=3397m, 2962m, 2925m, 1562s, 1455s, 1412s, 1383s, 1303s, 1239s, 1153 w, 1112 w, 1035m, 980m, 905m, 845s, 824m, 796m, 695s. Far IR (CsI): nu (cm-1)=216m nu(Cu-Br). 1H NMR (300MHz, DMSO-d6, delta): 7.83 (s, 1H, HC(3,5-Me2pz)3), 6.04 (s, 3H, 4-H-pz), 2.40, 2.22 (s, s, 9H, 9H, 3,5-Me). 13C{1H} NMR (300MHz, DMSO-d6, delta): 149.12 (3-Cquat-pz), 140.28 (5-Cquat-pz), 106.44 (4-C-pz), 70.67 (HC(3,5-Me2pz)3), 13.48,10.37 (3,5-Me). ESI(+)MS in MeCN (m/z assignment, % intensity): 204 ({[HC(3,5-Me2pz)3]Cu+MeCN}+, 100), 361 ({[HC(3,5-Me2pz)3]Cu}+, 26).

As the paragraph descriping shows that 7787-70-4 is playing an increasingly important role.

Reference£º
Article; Mahmoud, Abdallah G.; Martins, Luisa M.D.R.S.; Guedes da Silva, M. Fatima C.; Pombeiro, Armando J.L.; Inorganica Chimica Acta; vol. 483; (2018); p. 371 – 378;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”