Interesting scientific research on Cuprous thiocyanate

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Thirty-two aryl-substituted 2-benzothiazolamines have been tested for their ability to modulate sodium flux in rat cortical slices. A QSAR analysis, applied to these derivatives, showed a trend toward increasing potency as sodium flux inhibitors with increasing lipophilicity, decreasing size, and increasing electron withdrawal of the benzo ring substitutents. Additionally, 4- or 5-substitution of the benzo ring was found to decrease potency. The combination of increased lipophilicity, small size, and electron withdrawal severely limited which groups were tolerated on the benzo ring, thus suggesting that the optimal substitution patterns have been prepared within this series. Nine of these compounds were potent inhibitors of veratridine-induced sodium flux (NaFl). These nine compounds also proved to be anticonvulsant in the maximal electroshock (MES) assay. Fourteen additional 2-benzothiazolamines demonstrated activity in the MES screen, yet exhibited no activity in the NaFl assay. These derivatives may be interacting at the sodium channel in a manner not discernible by the flux paradigm, or they may be acting by an alternative mechanism in vivo.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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A method of using certain 3-aryl-2-hydroxypropionic acid derivatives and analogs in the treatment of hypertension.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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Six mixed-valence CuICuII compounds containing 4?-(4-pyridyl)-2,2?:6?,2?-terpyridine (L1) or 4?-(2-pyridyl)-2,2?:6?,2?-terpyridine (L2) were prepared under the hydrothermal and ambient conditions, and their crystal structures were determined by single-crystal X-ray diffraction. Selection of CuCl 2·2H2O or Cu(CH3COO)2· H2O with the L1 ligand and NH4SCN, KI, or KBr under hydrothermal conditions afforded 1-dimensional mixed-valence Cu ICuII compounds [Cu2(L1)(mu-1,1-SCN)(mu-Cl) Cl]n (1), [Cu2(L1)(mu-l)2Cl]n (2), [Cu2(L1)(mu-Br)2Br]n (3), and [Cu 2(L1)(mu-1,3-SCN)2(SCN)]n (4), respectively. Compound 5, prepared by layering with CuSCN and L1, is a 2-dimensional bilayer structure. In compounds 1-5, the L1 ligand and X (X = Cl, Br, I, SCN) linked between monovalent and divalent copper atoms resulting in the formation of mixed-valence rectangular grid-type M4L4 or M 6L6 building blocks, which were further linked by X (X = Cl, Br, I, SCN) to form 1- or 2-dimensional polymers. The sizes of M 4L4 units in 1-4 were fine-tuned by the sizes of X linkers. Reaction of Cu(CH3COO)2·H2O with L2 and NH4SCN under hydrothermal conditions gave mixed-valence CuICuII compound [Cu2(L2)(mu-1,3-SCN) 3]n (6). Unlike those in 1-5, the structure of 6 was constructed from thiocyanate groups and the pendant pyridine of L2 left uncoordinated. The temperature-dependent magnetic susceptibility studies on compounds 1 and 4 showed the presence of mixed-valence electronic structure.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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Compounds of general formula (I) and compositions comprising compounds of general formula I that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methylsulfinyl-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di(methylsulfinyl)xanthone-2-carboxylic acid are illustrated as representative compounds.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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The flexible, multi dentate, heteroelemental, dipodal ligands; bis(2pyridylthio)methane, (PyS)2CH2 (Py = pyridyl = C5H4N), (PymS)2CH2, bis(2pyrimidylthio)methane, and bipyrimidyldisulfide, (PymS)2 (Pym = pyrimidine, C4H3N2), were reacted with a series of copper precursors to determine whether monomeric compounds, cubane clusters or polymeric chains would be obtained. Copper(II) chloride, copper(I) cyanide and copper(I) thiocyanate afforded infinite polymeric chains while copper(I) iodide afforded tetranuclear clusters supported by two ligand molecules. All products were characterized in the solid-state by X-ray crystallography.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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Thiazolidinone derivatives of formula (I): STR1 in which R1, R2, R3, R4 and R5 are various atoms or organic groups, Ar is an aromatic group and n is an integer have valuable pharmacological activities including the ability to reduce blood glucose levels and blood lipid levels.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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The hydro/solvothermal reactions of Cu(I)/Cu(II) salt, NaN3, and acetonitrile in water or methanol yield two noninterpenetrated supramolecular networks containing 1D hexagonal and square nanochannels, {[Cu(Mtta)]·0.17H2O}n (1) and its pseudopolymorph [Cu(Mtta)]n (2) (Mtta = 5-methyl tetrazolate), involving ligand insitu formation by cycloaddition of nitriles and azides. The copper-(I) centers in both complexes are all bridged by Mtta ligands, forming the different shapes of the cavity. 1 exhibits an unprecedented uniform (8, 3) topological metal network, whereas 2 is a 3-connected (8210) metal net.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

Interesting scientific research on Cuprous thiocyanate

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Copper(I) complexes are studied for various potential applications due to their luminescence properties. However, issues have been identified regarding the stability of heteroleptic compounds. As a novel strategy, we propose to modify existing copper(I) complexes by introduction of molecular bridges between the different ligands. We report the synthesis and chemical properties of the complexes of 8-(diphenylphosphanyl-oxy)quinoline (POQ), a combination of a phosphine and a N-heterocycle with CuX (X = Cl, Br, I and SCN). The photophysical properties of the materials were studied. However, all four compounds were found to be labile in solution upon contact with trace amounts of water. Two POQ complexes and the decomposition products were identified as tetraphenyldiphosphoxane complexes with single crystal X-ray diffraction. We propose a design rule to prevent this behavior in future development steps.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

 

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The characteristics of copper oxide clusters in their neutral, anionic and cationic states were investigated using density functional theory calculations. Linear or near linear structures were shown by the ground state structures. A study on the ground state of a cluster, investigated within the hybrid and generalized gradient approximation DFT methods, was presented. The time-dependent density functional theory was applied for determining the low-lying excited states for the clusters. The role played by the excited states in assigning features in the photoelectron spectra was analyzed.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”