Tag: M.W:400-500

Name: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, is researched, Molecular C20H28ClN3O6, CAS is 89396-94-1, about Imidapril: a review of its use in essential hypertension, type 1 diabetic nephropathy and chronic heart failure. Author is Robinson, Dean M.; Curran, Monique P.; Lyseng-Williamson, Katherine A..

A review. Imidapril (Tanatril), through its active metabolite imidaprilat, acts as an ACE inhibitor to suppress the conversion of angiotensin I to angiotensin II and thereby reduce total peripheral resistance and systemic blood pressure (BP). In clin. trials, oral imidapril was an effective antihypertensive agent in the treatment of mild to moderate essential hypertension. Some evidence suggests that imidapril also improves exercise capacity in patients with chronic heart failure (CHF) and reduces urinary albumin excretion rate in patients with type 1 diabetes mellitus. Imidapril was well tolerated, with a lower incidence of dry cough than enalapril or benazepril, and is a first choice ACE inhibitor for the treatment of mild to moderate essential hypertension. Pharmacol. Properties The active metabolite of imidapril is imidaprilat, which inhibits the conversion of angiotensin I to angiotensin II. Lowering of plasma and tissue angiotensin II levels results in peripheral vasodilation, reduced systemic BP, renoprotective effects in patients with type 1 diabetes, and decreased renal sodium and water retention. After multidose oral administration in patients with hypertension, steady-state maximum plasma concentrations of imidapril (≈30 ng/mL) and imidaprilat (≈20 ng/mL) are achieved in a median time of 2 and 5 h. In healthy men 25.5% of a single dose of imidapril 10mg was excreted in the urine within 24 h. Elimination occurs primarily through excretion in the urine (≈40%) and feces (≈50%); after oral administration in healthy volunteers, the terminal elimination half-life of imidaprilat is ≈24 h. Therapeutic Efficacy In randomized controlled trials, oral imidapril was effective in the treatment of adults with mild to moderate essential hypertension. In short-term (2- and 4-wk) dose-finding trials, imidapril dosages of 10-40 mg/day were significantly more effective than placebo, inducing 11-15mm Hg reductions in sitting diastolic BP (sDBP; primary endpoint). In comparative 12- and 24-wk trials, imidapril 5-20 mg/day induced reductions in mean sDBP of 10-15mm Hg that did not differ significantly from those induced by hydrochlorothiazide 12.5-50 mg/day or captopril 50-100 mg/day (primary endpoint), nor those induced by enalapril 5-10 mg/day or nifedipine sustained release (SR) 40-80 mg/day (secondary endpoint). In addition, reductions in sDBP and sitting systolic BP (co-primary endpoints) with imidapril did not differ from those induced by candesartan 4-16 mg/day. Favorable reductions in sDBP were maintained during 6-mo and 52-wk noncomparative trials. In patients with type 1 diabetes, the urinary albumin excretion rate (a marker of nephropathy) increased by 72% in placebo recipients, but declined by 41% in imidapril 5 mg/day and by 6% in captopril 37.5 mg/day recipients during a mean treatment period of 1.5 years. In patients with CHF, mean total exercise time increased from baseline in imidapril 2.5-10 mg/day recipients in a dose-related manner after 12-wk of treatment; a 9.7% increase with imidapril 10 mg/day was significantly greater than the change with placebo (+0.7%). Tolerability Overall, imidapril was relatively well tolerated, with an incidence of adverse events in pooled analyses of data from clin. trials and post-marketing surveillance (n = 6632) of 6.6%. The most commonly reported adverse events were cough, hypotension, dizziness and pharyngeal discomfort. During 2- and 4-wk trials, the overall incidence of adverse events was 26% and 40% in recipients of imidapril 2.5-40 mg/day compared with 35% and 37% in placebo recipients. In comparative trials, the incidence of treatment-related adverse events in imidapril vs. enalapril recipients in two 12-wk trials were 5.6% vs. 12.2% and 12.0% vs. 14.1%; in other 12-wk trials treatment-related adverse events were observed in 24.2% of imidapril vs. 41.7% of nifedipine SR, and 20.7% of imidapril vs. 46.4% of captopril recipients, while the overall incidence of adverse events in imidapril vs. candesartan recipients was 11.7% vs. 16.1%. The incidences of adverse events in a 24-wk trial were 46.0% with imidapril and 52.8% with hydrochlorothiazide. In longer-term trials, adverse events were reported by 61.6% of imidapril recipients in the 52-wk trial; however, only 1.7% of imidapril recipients in a 6-mo field trial experienced adverse events considered related to ACE inhibitor treatment. In prospective investigations in hypertensive patients, switching to imidapril did not reduce the incidence of cough (a class effect of ACE inhibitors) in a small open-label trial in hypertensive patients already experiencing ACE-inhibitor induced cough; however, in a large crossover trial, the incidence of cough with imidapril (15.2%) was less than half that with enalapril (38.6%). In addition, cough disappeared in 52.9% of enalapril recipients switched to imidapril, and in patients without cough during imidapril treatment, switching to enalapril induced cough in 20.9%. In contrast, in patients without cough during initial enalapril treatment, only 0.9% developed cough during subsequent imidapril treatment. In a second large, double-blind crossover trial, the incidence of cough was significantly lower in imidapril than benazepril recipients.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Formula: C27H18AlN3O3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Aluminum triquinolin-8-olate, is researched, Molecular C27H18AlN3O3, CAS is 2085-33-8, about Highly transparent, low sheet resistance and stable Tannic acid modified-SWCNT/AgNW double-layer conductive network for organic light emitting diodes. Author is Zhu, Ze-Ru; Geng, Wenming; Zhu, Qingxia; Ethiraj, Anita Sagadevan; Wang, Tao; Jing, Li-Chao; Ning, Yu-Jie; Tian, Yi; Geng, Wen-Hao; Wu, Lei; Geng, Hong-Zhang.

In this paper, we used tannic acid (TA) functionalized carbon nanotubes (TCNTs), and silver nanowires (AgNWs) to construct a new type of transparent conductive film (TCF) with a double-layered conductive network structure. The hybrid film exhibits excellent light transmittance, high elec. conductivity, ultra-flexibility, and strong adhesion. These outstanding performances benefit from the filling and adhesion of hydrophilic TCNT layers to the AgNW networks. Besides, we introduced the post-treatment process of mech. pressing and covering polymer conductive polymer PEDOT:PSS, which obtained three layers of TCNT/AgNW/PEDOT hybrid film and greatly improved the comprehensive properties. The hybrid film can reach a sheet resistance of 9.2 ω sq-1 with a transmittance of 83.4% at 550 nm wavelength, and a low root mean square (RMS) roughness (approx. 3.8 nm). After 10 000 bends and tape testing, the conductivity and transmittance of the hybrid film remain stable. The resistance of the film has no significant degradation after 14 d of exposure to high temperature of 85°C and humidity of 85%, indicating excellent stability. The organic light-emitting diodes (OLEDs) with TCNT/AgNW/PEDOT hybrid film as anode exhibit high c.d. and luminosity, confirming this process has considerable potential application in photovoltaic devices.

This literature about this compound(2085-33-8)Formula: C27H18AlN3O3has given us a lot of inspiration, and I hope that the research on this compound(Aluminum triquinolin-8-olate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride( cas:89396-94-1 ) is researched.Recommanded Product: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride.Saruta, Takao; Omae, Teruo; Kuramochi, Morio; Iimura, Osamu; Yoshinaga, Kaoru; Abe, Keishi; Ishii, Masao; Watanabe, Tsutomu; Takeda, Tadanao published the article 《Imidapril hydrochloride in essential hypertension: A double-blind comparative study using enalapril maleate as a control》 about this compound( cas:89396-94-1 ) in Journal of Hypertension. Keywords: imidapril hydrochloride enalapril maleate antihypertensive. Let’s learn more about this compound (cas:89396-94-1).

The objective was to assess the value of using imidapril hydrochloride (ACE/TA-6366), a long-acting angiotensin converting enzyme (ACE) inhibitor developed in Japan, to treat patients with essential hypertension. A double-blind, comparative, phase III study was carried out using enalapril maleate as a control, with a 4-wk observation period and a 12-wk treatment period. Both drugs were started at a dose of 5 mg once a day, increasing to 10 mg in patients whose antihypertensive response was insufficient after 4 wk. The study included 231 outpatients aged 30-74 yr; of these, 108 in the imidapril group and 115 in the enalapril group were assessed. There were no differences in background factors between groups. An adequate antihypertensive effect was observed in 71.3% (77/108) in the imidapril group and in 66.1% (76/115) in the enalapril group, with no significant difference between groups. The pulse rate was unchanged in both groups. The drug had no adverse effects in 86.1% (93/108) of the imidapril group and 79.1% (91/115) of the enalapril group, with no significant difference between groups. Adverse drug effects were observed in 5.6% (6/108) of the imidapril group and 12.2% (14/115) of the enalapril group. Cough was the most frequent side effect, reported in 0.9% (1/108) of the imidapril group and 7.0% (8/115) of the enalapril group. Other side effects were reported in 4.6% (5/108) of the imidapril group and 5.2% (6/115) of the enalapril group. Abnormal laboratory values were observed in 3.7% (4/108) of the imidapril group and 0.9% (1/115) of the enalapril group. Imidapril showed excellent clin. efficacy and safety compared to enalapril. The low incidence of cough is of particular interest.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Analysis of Risk Factors in Human Bioequivalence Study That Incur Bioinequivalence of Oral Drug Products, published in 2009-02-28, which mentions a compound: 89396-94-1, Name is (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride, Molecular C20H28ClN3O6, Application of 89396-94-1.

In the study of human bioequivalence (BE), newly developed oral products sometimes fail to prove BE with a reference product due to the high variability in pharmacokinetic (PK) parameters after oral absorption. In this study, risk factors that incur bioinequivalence in BE study were analyzed by applying the Biopharmaceutics Classification System (BCS). Forty-four generic products were selected from a database of BE studies in the past 10 years at Towa Pharmaceutical Co., Ltd. (Osaka, Japan), and 90% confidence interval (CI) of AUC and Cmax in human BE study for all products were converted into coefficient of variation (CV90). Then, the required number of subjects to confirm BE was estimated from the 90% CI in human BE study of new products. It was found that both the permeability of drugs to human intestinal membrane (Peff) and the dose number calculated from their water solubility did not correlate well to CV90 and the estimated subject number in human BE study, suggesting the contribution of other factors to cause the variability in oral drug absorption. As the PK parameter of drugs, the value of AUC/dose was calculated and plotted against CV90 and the estimated subject number by classifying drugs into 4 BCS classes. For drugs in classes 1 and 3, AUC/dose gave a clear criterion to distinguish the drugs with a high risk of bioinequivalence, where drugs with low AUC/dose showed high CV90 and large number of subjects. It was suggested that the high metabolic clearance (for class 1 drug) and low oral absorption (for class 3 drug) could be significant factors to incur bioinequivalence in human BE study, although for drugs in classes 2 and 4, clear factors were not defined. Consequently, for drugs in BCS classes 1 and 3, risks in human BE study to incur bioinequivalence could be predicted by calculating the AUC/dose. In the case of generic drugs, since the parameter of AUC/dose is available before initiating human BE study, this finding is expected to promote an efficient and cost-saving strategy for the development of oral drug products.

As far as I know, this compound(89396-94-1)Application of 89396-94-1 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Mondal, Kali Prasanna; Bera, Sambhunath; Gupta, Ajay; Kumar, Dileep; Reddy, V. Raghavendra; Das, Gangadhar; Singh, Arnab; Yamada- Tamakura, Yukiko published an article about the compound: Aluminum triquinolin-8-olate( cas:2085-33-8,SMILESS:[O-]C1=C2N=CC=CC2=CC=C1.[O-]C3=C4N=CC=CC4=CC=C3.[O-]C5=C6N=CC=CC6=CC=C5.[Al+3] ).Application In Synthesis of Aluminum triquinolin-8-olate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2085-33-8) through the article.

Growth behavior and evolution of magnetism as a function of Fe thin film thickness onto organic semiconductor tris(8-hydroxyquinoline)-aluminum, (Alq3) thin film was investigated in-situ using elec. resistance and magneto-optic Kerr effect (MOKE) measurements, resp. The variation of elec. resistance with Fe film thickness reveals the Volmer-Weber growth of Fe on Alq3 film. RHEED (RHEED) pattern resembles polycrystalline BCC structure of Fe. Ex-situ x-ray reflectivity (XRR) measurement from the Fe/Alq3/Si sample reveals that Fe diffuses into Alq3 to form an alloy layer of 50 Å thickness with Fe volume fraction of 0.4. In-situ MOKE study affirms anomalous magnetic behavior at the initial stage of Fe growth. Initially hysteresis loop appears and develops in a particular direction, and then vanishes at certain thickness. With further growth of Fe hysteresis loop appears again and grows in the opposite direction. The observed unusual changes in magnetic behavior as a function of Fe thickness may be explained in terms of the contribution from the magnetic Fe-Alq3 alloy present in the intermix layer, the metallic Fe on top of Alq3 layer, and their antiferromagnetic coupling.

From this literature《Growth behavior, physical structure, and magnetic properties of iron deposited on Tris(8-hydroxy quinoline)-aluminum》,we know some information about this compound(2085-33-8)Application In Synthesis of Aluminum triquinolin-8-olate, but this is not all information, there are many literatures related to this compound(2085-33-8).

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 89396-94-1, is researched, Molecular C20H28ClN3O6, about Pharmacological studies on TA-6366, a new ACE inhibitor: II. Effect of long-term administration from the pre-hypertensive stage on blood pressure, relative heart weight and ACE activity of various tissues in spontaneously hypertensive rats (SHRs), the main research direction is TA6366 blood pressure heart ACE pharmacol.HPLC of Formula: 89396-94-1.

The long-term oral administration of TA-6366 (I) (5 mg/kg/day) from 4-wk old impeded the genetic hypertension development with only a slight decrease in heart rate in spontaneously hypertensive rats (SHRs). However, the lower dose (1 mg/kg/day) of TA-6366 did not affect the development, but it lowered blood pressure after the development was almost accomplished. Concomitantly, relative heart weights in both the groups were markedly decreased to almost the same degree. The reduction of ACE activity in the aorta, brain and lung of both groups was found at 24 h after the final administration, particularly at the 5 mg/kg/day dose; and that of the aorta was kept at almost the same low level even on the 9th day of withdrawal. After withdrawal of TA-6366 (5 mg/kg/day), the decrease in blood pressure was sustained at least for 10 wk. The beneficial effect of TA-6366 on the hypertension development in SHRs seems to be related to its strong and long-lasting ACE inhibition, especially in the vasculature.

From this literature《Pharmacological studies on TA-6366, a new ACE inhibitor: II. Effect of long-term administration from the pre-hypertensive stage on blood pressure, relative heart weight and ACE activity of various tissues in spontaneously hypertensive rats (SHRs)》,we know some information about this compound(89396-94-1)HPLC of Formula: 89396-94-1, but this is not all information, there are many literatures related to this compound(89396-94-1).

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Aluminum triquinolin-8-olate(SMILESS: [O-]C1=C2N=CC=CC2=CC=C1.[O-]C3=C4N=CC=CC4=CC=C3.[O-]C5=C6N=CC=CC6=CC=C5.[Al+3],cas:2085-33-8) is researched.HPLC of Formula: 60804-74-2. The article 《Preparation and Optoelectronic Properties of Iridium (III) Complexes Based on 1,3,4-Oxadiazole and β-diketones》 in relation to this compound, is published in Springer Proceedings in Physics. Let’s take a look at the latest research on this compound (cas:2085-33-8).

Preparation and characterizations of iridium (III) complexes namely {2-(4-biphenylyl)-5-(4-tertbutylphenyl)-[1,3,4]-oxadiazolato-N4,C2}2 Ir(theonyltrifluoacetone) [(PBD)2Ir(tta)] and {2-(4-biphenylyl-5-(4-tertbutylphenyl)-[1,3,4]-oxadiazolato-N4,C2}2 Ir(2,2,6,6-tetramethyl-3,5-heptanedione)[(PBD)2Ir(tmd)] having two cyclometalated ligands (CN) and a bidentate diketone ligand (X) denoted as [CN)2Ir(X)] where X is a β-diketone with trifluoromethyl, theonyl or t-Bu groups, are detailed. Fourier transform IR (FTIR) spectroscopy with CHN anal. structurally confirms the formation of these complexes. These metal complexes proved good thermal stability in air up to 300 °C. The UV-Visible spectra of these complexes revealed λmax at 362 and 370 nm for [(PBD)2Ir(tta)] and [(PBD)2Ir(tmd)], resp. The photoluminescence spectra of the complexes showed maximum emission at 549 and 559 nm, resp. The electroluminescent properties of these complexes have also been studied through fabricating multilayer devices with the structure ITO/α-NPD(30 nm)/(PBD)2Ir(tta) doped CBP(35 nm)/BCP(6 nm)/Alq3(28 nm)/LiF(1 nm)/Al and ITO/α-NPD(30 nm)/(PBD)2Ir(tmd) doped CBP(35 nm)/BCP(6 nm)/Alq3(28 nm)/LiF(1 nm)/Al. The electroluminescent spectra showed maximum emission at 555 and 563 nm, resp.

From this literature《Preparation and Optoelectronic Properties of Iridium (III) Complexes Based on 1,3,4-Oxadiazole and β-diketones》,we know some information about this compound(2085-33-8)Category: copper-catalyst, but this is not all information, there are many literatures related to this compound(2085-33-8).

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Matsui, Kazuki; Takeuchi, Susumu; Haruna, Yuka; Yamane, Miki; Shimizu, Takahiro; Hatsuma, Yoshiki; Shimono, Norihito; Sunada, Machiko; Hayakawa, Masakane; Nishida, Tomo; Ito, Shusei; Ide, Masashi; Seino, Maki; Sugihara, Masahisa; Minagawa, Yasushi; Tachiki, Hidehisa published the article 《Transverse comparison of mannitol content in marketed drug products: Implication for no-effect dose of sugar alcohols on oral drug absorption》. Keywords: mannitol content products oral drug delivery system absorption.They researched the compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride( cas:89396-94-1 ).Synthetic Route of C20H28ClN3O6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:89396-94-1) here.

Some of pharmaceutical excipients are known to affect oral drug absorption via various mechanisms. Among diverse excipients, sugar alcs. (e.g. mannitol and sorbitol) are regarded as critical excipients that significantly alter drug absorption by osmotic effect. This recognition is based on the previous findings that several grams of sugar alcs. exhibited clear impact on the bioavailability/bioequivalence of certain drugs. However, commonly administered oral drug products contain less amount of sugar alc., thus, such a significant impact on drug absorption is questionable. The purpose of this research was to retrospectively estimate the no-effect dose of mannitol that may not affect oral absorption of BCS class I and III drugs. Mannitol content in marketed oral drug products (16 active pharmaceutical ingredients, 132 drug products) was quantified by means of reverse engineering or questionnaire survey to 11 generic drug manufacturers headquartered in Japan. The transverse comparison suggested that “”practical”” amount of mannitol may not have significant impact on oral absorption of investigated mols. This implication can be utilized to determine a no-effect threshold of sugar alc. in the context of BCS-based biowaiver guideline as well as other guidelines such as formulation change and pharmaceutical line extension.

From this literature《Transverse comparison of mannitol content in marketed drug products: Implication for no-effect dose of sugar alcohols on oral drug absorption》,we know some information about this compound(89396-94-1)Synthetic Route of C20H28ClN3O6, but this is not all information, there are many literatures related to this compound(89396-94-1).

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Formula: C27H18AlN3O3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Aluminum triquinolin-8-olate, is researched, Molecular C27H18AlN3O3, CAS is 2085-33-8, about High-Performance Transparent PEDOT: PSS/CNT Films for OLEDs. Author is Tian, Ying; Wang, Tao; Zhu, Qingxia; Zhang, Xingcai; Ethiraj, Anita Sagadevan; Geng, Wen-Ming; Geng, Hong-Zhang.

Improved OLED systems have great potential for next-generation display applications. Carbon nanotubes (CNTs) and the conductive polymers poly (3,4-ethylenedioxythiophene): poly (styrene sulfonate) (PEDOT: PSS) have attracted great interest for advanced applications, such as optoelectronic products. In this paper, the simultaneous enhancement of the conductivity, roughness, and adhesion properties of transparent conductive films with PEDOT: PSS/CNTs is reported. These films prepared by a simple spin-coating process were successfully used to produce high-performance organic light-emitting diodes (OLEDs) with an improved lifetime. Addition of PEDOT: PSS lowered the film sheet resistance and CNTs helped to enhance the stability and maintain the lifetime of the OLEDs. In addition, treatment with methanol and nitric acid changed the morphol. of the polymer film, which led to greatly reduced sheet resistance, enhanced substrate adhesion, and reduced film roughness. The best performance of the film (PEDOT: PSS: CNT = 110: 1, W/W) was 100.34 Ω/sq.@ 90.1 T%. High transmittance, low sheet resistance, excellent adhesion, and low roughness (3.11 nm) were achieved synchronously. The fabricated OLED demonstrated a low min. operating voltage (3 V) and could endure high voltage (20 V), at which its luminance reached 2973 cd/m2. Thus, the incorporation of CNTs within PEDOT: PSS electrodes has great potential for the improvement of the performance of OLED devices.

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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Yun, Ji Hye; Myung, Ja Hye; Kim, Hye Jin; Lee, Sibeum; Park, Jong-Sei; Kim, Won; Lee, Eun-Hee; Moon, Cheol Jin; Hwang, Sung-Joo published an article about the compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride( cas:89396-94-1,SMILESS:O=C([C@H](CN1C)N(C([C@@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C)=O)C1=O)O.[H]Cl ).Related Products of 89396-94-1. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:89396-94-1) through the article.

The purpose of the present study was to develop a standard protocol for imidapril hydrochloride bioequivalence testing. For this reason, a specific LC-MS method was developed and validated for the determination of imidapril in human plasma. A solid-phase extraction cartridge, Sep-pak C18, was used to extract imidapril and ramipril (an internal standard) from deproteinized plasma. The compounds were separated using a XTerra MS C18 column (3.5 μm, 2.1×150 mm) and acetonitrile-0.1% formic acid (67:33, volume/volume) adjusted to pH 2.4 by 2 mmol/L ammonium formic acid, as mobile phase at 0.3 mL/min. Imidapril was detected as m/z 406 at a retention time of ca. 2.3 min, and ramipril as m/z 417 at ca. 3.6 min. The described method showed acceptable specificity, linearity from 0.5 to 100 ng/mL, precision (expressed as a relative standard deviation of less than 15%), accuracy, and stability. The plasma concentration-vs.-time curves of 8 healthy male volunteers administered a single dose of imidapril (10 mg), gave an AUC12hr of imidapril of 121.48±35.81 ng mL-1 h, and Cmax and Tmax values of 32.59±9.76 ng/mL and 1.75±0.27 h. The developed method should be useful for the determination of imidapril in plasma with sufficient sensitivity and specificity in bioequivalence study.

From this literature《LC-MS determination and bioavailability study of imidapril hydrochloride after the oral administration of imidapril tablets in human volunteers》,we know some information about this compound(89396-94-1)Related Products of 89396-94-1, but this is not all information, there are many literatures related to this compound(89396-94-1).

Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”