Tag: M.W:400-500

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.578743-87-0,[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride,as a common compound, the synthetic route is as follows.

578743-87-0, General procedure: Cu(I)-NHC 1a-g (0.04 mmol, 1.0 equiv) and CDCl3 (0.4 mL, degassed by bubbling argon for 30 min) were added into a flame-dried NMR tube. (CD3)2SO (0.4 mL) was used for 1h (0.04 mmol), 1i (0.02 mmol), and 1j (0.02 mmol). The NMR tube was closed with a septum and equipped with an air balloon (approximate 500 mL) containing approximately 100 mL of O2 (4.5 mmol, 112 equiv.) and approximately 12.6 mL of H2O (gas, 0.56 mmol, 14 equiv., air relative humidity = 75%). The solution (not agitated) was placed at room temperature and was monitored by 1H NMR. 100 C was used for the decomposition of 1h, and 150 C was used for the decomposition of 1i and 1j. The precipitate in the NMR tube was removed by quick filtration using a membrane filter before each 1H NMR measurement. The ratio of Cu-NHC, urea, and imidazolium were calculated through the integration of 1H NMR, using the normalization method. The characterization of products could be found in the previous study [32].

The synthetic route of 578743-87-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Dazhi; Ollevier, Thierry; Journal of Organometallic Chemistry; vol. 906; (2020);,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride, cas is 578743-87-0, it is a common heterocyclic compound, the copper-catalyst compound, its synthesis route is as follows.,578743-87-0

Chloro[l ,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I) (121.9 mg, 0.25 mmol) and silver triflate (64.2 mg, 0.25 mmol) were mixed under nitrogen in 25 mL flask and 10 mL of dry THF were added. Reaction mixture was stirred at RT for 30 minutes. Solution of 1 , 10-phenanthroline (45.05 mg, 0.25 mmol) in dry THF (5 mL) was added. Reaction mixture turned yellow and was stirred at RT overnight. Resulting mixture was filtered through Celite and solvent was evaporated on rotovap. Recrystallization from CH2Ch by vapor diffusion of Et20 gave 120 mg (61.4%) of yellow crystals. Anal, calcd. for C40H44CUF3N4O3S: C, 61.48; H, 5.68; N, 7.17; Found: C, 61.06; H, 5.61; N, 7.14. Structure was confirmed by IH-NMR spectrum of [(IPR)Cu(phen)]OTf (CDCb, 400MHz).

578743-87-0 is used more and more widely, we look forward to future research findings about [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride

Reference£º
Patent; THE UNIVERSITY OF SOUTHERN CALIFORNIA; THOMPSON, Mark; DJUROVICH, Peter; KRYLOVA, Valentina; WO2011/63083; (2011); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

578743-87-0, [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(2-Pyridyl)benzimidazole (78.1 mg, 0.4 mmol) was dissolved in 10 mL of dry THF under N2 and this solution was transferred via cannula to suspension of sodium hydride (17.6 mg, 0.44 mmol, 60% in mineral oil) in dry THF. Reaction mixture was stirred at RT for 1 h and then chloro[l,3-bis(2,6-di-i-propylphenyl)imidazol-2- ylidene]copper(I) (195.1 mg, 0.4 mmol) was added. Reaction mixture was stirred at RT for 3 h. The resulting mixture was filtered through Celite and solvent was removed by rotary evaporation. Recrystallization by vapor diffusion of Et20 into a CH2C12 solution of product gave 154 mg (59.5%>) of dark yellow crystals. Anal, calcd. for C39H44CuN5: C, 72.47; H, 6.86; N, 10.48; Found: C, 72.55; H, 6.94; N, 10.84., 578743-87-0

578743-87-0 [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride 0, acopper-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; THE UNIVERSITY OF SOUTHERN CALIFORNIA; THOMPSON, Mark; DJUROVICH, Peter; KRYLOVA, Valentina; WO2011/63083; (2011); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

As a common heterocyclic compound, it belong copper-catalyst compound,[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride,578743-87-0,Molecular formula: C27H36ClCuN2,mainly used in chemical industry, its synthesis route is as follows.,578743-87-0

General procedure: To an oven-dried screwed 20 mL vial were added (NHC)CuCl (c7 or c8, 0.2 mmol) suspended in dry THF (3 mL); in another vial, [tBu3PN]Li (1b, 42.3 mg, 0.95 eq.) was also dissolved in dry THF (3 mL), then the vial was put into glove-box fridge (-35 C) for one hour. Then the cold mixture was dropped into the (NHC)CuCl/THF suspension slowly under stirring and the suspension was turned into clear solution as the lithium salt added. After addition, the reaction mixture was kept at room temperature in glove box for 13 hours. After the reaction was completed, the volatile was removed under vacuum and dry hexane or pentane (7 mL) was added into the formed oily residue. The suspension obtained was kept stirring for another 15 mins at room temperature, then filtered through a short pad of neutral celite to get rid of precipitate. The filtrate was cooled down in the fridge (-35 C) for 3-4 hours to remove the unreacted lithium salt 1b further. Repeated once again to get the clear hexane or pentane filtrate. The filtrate was evaporated until white crystallized solid was formed, which is the catalytic active species (3 or 4). IPrCuCl (c7, 97 mg, 0.2 mmol); Obtain IPrCuNPtBu3 (3, 99 mg, 78%) as Colorless Solid; 1H NMR (C6D6, 600 MHz) delta 7.26-7.21 (br, m, 4H, m-ArH), 7.17-7.14 (br, m, 2H, p-ArH), 6.40 (s, 2H, NCH=), 2.83 (sep, 4H, J = 6.6 Hz, CH(CH3)2), 1.61 (d, 12H, J = 6.6 Hz, CH(CH3)2), 1.37 (d, 27H, J(PH) = 10.8 Hz, P(C(CH3)3)3), 1.20 (d, 12H, J = 6.6 Hz, CH(CH3)2); 13C NMR (C6D6, 151 MHz) delta 146.18, 136.50, 130.42, 128.68, 124.42, 122.05, 40.78, 40.49, 31.01, 29.33, 25.04, 24.42; 31P NMR (C6D6, 243 MHz) delta 26.35 (s); Elemental analysis calcd for [C39H63CuN3P+0.67 THF]: C, 69.84; H, 9.61; N, 5.86. Found: C, 69.48; H, 9.90; N, 6.19.

With the synthetic route has been constantly updated, we look forward to future research findings about [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride,belong copper-catalyst compound

Reference£º
Article; Bai, Tao; Yang, Yanhui; Han, Chao; Tetrahedron Letters; vol. 58; 15; (2017); p. 1523 – 1527;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

578743-87-0, [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

578743-87-0, Chloro[l ,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I) (487.59 mg, 0.25 mmol) and silver triflate (64.2 mg, 0.25 mmol) were mixed under nitrogen in 25 mL flask and 10 mL of dry THF were added. Reaction mixture was stirred at RT for 30 minutes. Solution of 1 ,2-bis(diphenylphosphino)benzene (1 1 1.6 mg, 0.25 mmol) in dry THF (5 mL) was added. Reaction mixture was stirred at RT overnight. Resulting mixture was filtered through Celite and solvent was evaporated on rotovap. Recrystallization from CH2CI2 by vapor diffusion of Et20 gave 130 mg (49.6%) of white needle crystals. Structure confirmed by 1H-NMR spectrum of [(IPR)Cu(dppbz)]OTf (CDCb, 400MHz).

The synthetic route of 578743-87-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE UNIVERSITY OF SOUTHERN CALIFORNIA; THOMPSON, Mark; DJUROVICH, Peter; KRYLOVA, Valentina; WO2011/63083; (2011); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

578743-87-0, [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

578743-87-0, In a dry double-mouth bottle to place Pt – 2 (0.0594 g, 0.1 mmol), CuClNHC (0.0488 g, 0.1 mmol), vacuum pumping and nitrogen cycle three times, then the nitrogen flow by adding 10 ml ethanol, stirring reflux reaction for 4 hours, cooling to room temperature, then added potassium hexafluorophosphate (0.184 g, 1 mmol), stirring at the room temperature reaction 2 hours, filtered, concentrated filtrate, ethanol: dichloromethane=1:10 column, get the orange solid 0.047 g, and the yield is 40%.

578743-87-0 [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride 0, acopper-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Jiangsu University Of Science And Technology; Shi Chao; Li Qiuxia; Zhang Xinghua; (24 pag.)CN108690096; (2018); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.578743-87-0,[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride,as a common compound, the synthetic route is as follows.,578743-87-0

Carbazole (83.6mg, 0.5mmol) and NaH (12 mg, 0.5 mmol) was mixed with THF and 15 ml, atroom temperature under a nitrogen atmosphere until bubbling ceased (15 min) and stirred.Chloro [1,3-bis (2,6-diisopropylphenyl) imidazol-2-ylidene] was added copper (I) ((IPr) CuCl)(243.8mg, 0.5mmol), the reaction mixture was stirred for one hour did. Then, the mixture wasfiltered through a plug of Celite (registered trademark) under an inert atmosphere, and thesolvent was removed by rotary evaporation. The product was obtained as a white solid (170mg,55%).

The synthetic route of 578743-87-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Universal Display Corporation; Mark, E. Thomson; Peter, I. Jurobitchi; Valentina, Krirowa; (66 pag.)JP2015/91800; (2015); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.578743-87-0,[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride,as a common compound, the synthetic route is as follows.,578743-87-0

Chloro[l,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I) (195.1 mg, 0.4 mmol) and silver triflate (102.7 mg, 0.4 mmol) were mixed under nitrogen in 25 mL flask and 10 mL of dry THF were added. Reaction mixture was stirred at RT for 30 minutes.Solution of 2,2′-bipyridine (62.4 mg, 0.4 mmol) in dry THF (5 mL) was added. Reaction mixture turned orange and was stirred at RT overnight. Resulting mixture was filtered through Celite and solvent was evaporated on rotovap. Recrystallization from CH2CI2 by vapor diffusion of EtaO gave 215 mg (70.9%) of orange crystals. Anal, calcd. forC38H44CUF3N4O3S: C, 60.26; H, 5.86; N, 7.40; Found: C, 60.18; H, 5.82; N, 7.38. Structure was confirmed by iH-NMR spectrum of [(IPR)Cu(bipy)]OTf (CDCb, 400MHz).

As the paragraph descriping shows that 578743-87-0 is playing an increasingly important role.

Reference£º
Patent; THE UNIVERSITY OF SOUTHERN CALIFORNIA; THOMPSON, Mark; DJUROVICH, Peter; KRYLOVA, Valentina; WO2011/63083; (2011); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

578743-87-0, [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride is a copper-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,578743-87-0

In a dry double-mouth bottle to place Ir – 1 (0.0695 g, 0.1 mmol), CuClNHC (0.0488 g, 0.1 mmol), vacuum pumping and nitrogen cycle three times, then the nitrogen flow by adding 10 ml ethanol, stirring reflux reaction for 4 hours, cooling to room temperature, then added potassium hexafluorophosphate (0.184 g, 1 mmol), stirring at the room temperature reaction 2 hours, filtered, concentrated filtrate, ethanol: dichloromethane=1:10 column, get the orange solid 0.064 g, and the yield is 50%.

As the paragraph descriping shows that 578743-87-0 is playing an increasingly important role.

Reference£º
Patent; Jiangsu University Of Science And Technology; Shi Chao; Li Qiuxia; Zhang Xinghua; (24 pag.)CN108690096; (2018); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact.578743-87-0, [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride it is a common compound, a new synthetic route is introduced below., 578743-87-0

In a dry double-mouth bottle to place Pt – 1 (0.0544 g, 0.1 mmol), CuClNHC (0.0488 g, 0.1 mmol), vacuum pumping and nitrogen cycle three times, then the nitrogen flow by adding 10 ml ethanol, stirring reflux reaction for 4 hours, cooling to room temperature, then added potassium hexafluorophosphate (0.184 g, 1 mmol), stirring at the room temperature reaction 2 hours, filtered, concentrated filtrate, ethanol: dichloromethane=1:10 column, get the orange solid 0.045 g, and the yield is 40%.

The synthetic route of 578743-87-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Jiangsu University Of Science And Technology; Shi Chao; Li Qiuxia; Zhang Xinghua; (24 pag.)CN108690096; (2018); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”